458-72-0

Basic information

• Product Name: N-[(4-fluorophenyl)methyl]thiazole 2-amine
• Synonyms: N-[(4-fluorophenyl)methyl]thiazole 2-amine
• CAS NO: 458-72-0
• Molecular Weight: 208.259
• Mol File: 458-72-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-[(4-fluorophenyl)methyl]thiazole 2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(4-fluorophenyl)methyl]thiazole 2-amine(458-72-0)
• EPA Substance Registry System: N-[(4-fluorophenyl)methyl]thiazole 2-amine(458-72-0)

Safety Data

• Hazardous Substances Data: 458-72-0(Hazardous Substances Data)

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 659-41-6 4-fluorobenzenemethanamine hydrochloride 
• 623-46-1 1,2-dichloro-2-ethoxyethane 
• 405-74-3 1-(4-fluorobenzyl)thiourea 

Downstream Products

• 3830-97-5 N-(4-fluoro-benzyl)-N',N'-dimethyl-N-thiazol-2-yl-ethylenediamine 

Relevant articles and documents

Design, synthesis and biological evaluation of new 1,3-thiazole derivatives as potential anti-inflammatory agents

Thiazoles are widely recognized as nuclei of great value for obtaining molecules with various biological activities, including analgesic, anti-inflammatory, anti-HIV, antidiabetic, antitumor and antimicrobial. A library of 26 thiazole derivatives as fragments were designed, synthesized and evaluated for their anti-inflammatory activities. Some screened compounds showed promising results and were found to be potent in the series by inhibiting LPS-induced TNFα and IL-8 release with IC50 values in μM range without cytotoxic activity.