459217-07-3

Basic information

• Product Name: 1,4-Butanedione, 2-(1,3-diethyl-2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-1-(3-methylphen yl)-4-(3-pyridinyl)-
• CAS NO: 459217-07-3
• Molecular Formula: C27H27N3O3
• Molecular Weight: 441.53
• Mol File: 459217-07-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,4-Butanedione, 2-(1,3-diethyl-2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-1-(3-methylphen yl)-4-(3-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-Butanedione, 2-(1,3-diethyl-2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-1-(3-methylphen yl)-4-(3-pyridinyl)-(459217-07-3)
• EPA Substance Registry System: 1,4-Butanedione, 2-(1,3-diethyl-2,3-dihydro-2-oxo-1H-benzimidazol-5-yl)-1-(3-methylphen yl)-4-(3-pyridinyl)-(459217-07-3)

Safety Data

• Hazardous Substances Data: 459217-07-3(Hazardous Substances Data)

Upstream product

• 680189-16-6 (1,3-diethyl-2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-acetic acid 
• 864513-24-6 (1,3-diethyl-2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-acetonitrile 
• 864512-93-6 1,3-diethyl-5-hydroxymethyl-1,3-dihydro-benzoimidazol-2-one 
• 619-05-6 3,4-diaminobenzoic acid 
• 23814-14-4 2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-carboxylic acid 
• 6221-12-1 3-Bromoacetylpyridine 
• 459217-12-0 1,3-diethyl-5-(2-oxo-2-m-tolyl-ethyl)-1,3-dihydro-benzoimidazol-2-one 

Relevant articles and documents

Benzimidazolone p38 inhibitors

The synthesis and in vitro p38α activity of a novel series of benzimidazolone inhibitors is described. The p38α SAR is consistent with a mode of binding wherein the benzimidazolone carbonyl serves as the H-bond acceptor to Met109 of p38α in a manner analogous to the pyridine nitrogen of prototypical pyridylimidazole p38 inhibitors. Potent p38α activity comparable to that of several previously reported p38 inhibitors is observed for this novel chemotype.