6221-12-1

Basic information

• Product Name: 3-(2-bromoacetyl)pyridine
• Synonyms: 3-(2-bromoacetyl)pyridine;1-bromo-2(pyridin-3-yl)-2-ethanone;Ethanone, 2-broMo-1-(3-pyridinyl)-;3-(2-Bromoacetyl)
• CAS NO: 6221-12-1
• Molecular Formula: C₇H₆BrNO
• Molecular Weight: 200.03
• Mol File: 6221-12-1.mol
• Article Data: 22

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 3-(2-bromoacetyl)pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-bromoacetyl)pyridine(6221-12-1)
• EPA Substance Registry System: 3-(2-bromoacetyl)pyridine(6221-12-1)

Safety Data

• Hazardous Substances Data: 6221-12-1(Hazardous Substances Data)

Usage

General Description

3-(2-bromoacetyl)pyridine is a chemical compound that consists of a pyridine ring with a bromoacetyl group attached to it at the 3-position. It is a yellow crystalline solid that is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. The bromoacetyl group imparts reactivity to the molecule, allowing it to participate in various organic reactions such as nucleophilic substitution and condensation reactions. Its versatile reactivity and the presence of the pyridine ring make 3-(2-bromoacetyl)pyridine a valuable building block for the synthesis of complex organic molecules. Additionally, the compound can also be used as a reagent for the functionalization and modification of other organic molecules.

Upstream product

• 350-03-8 methyl-3-pyridylketone 
• 39972-50-4 2-diazo-1-(pyridine-3-yl)ethan-1-one 
• 6283-81-4 3-oxo-3-pyridin-3-yl-propionic acid ethyl ester 
• 60-29-7 diethyl ether 
• 21970-14-9 pyridin-3-ylmagnesium bromide 
• 108-24-7 acetic anhydride 

Downstream Products

• 4192-31-8 4-oxo-4-(pyridin-3-yl)butanoic acid 
• 690616-03-6 3-[2-(4,4'-dimethoxy-benzhydryl)-thiazol-4-yl]-pyridine 
• 30162-42-6 2-(3-Pyridyl)amino-4-(3-pyridyl)thiazol 
• 30235-27-9 4-(pyridin-3-yl)thiazol-2-amine 
• 391906-07-3 (1R)-2-bromo-1-(3-pyridinyl)-1-ethanol 
• 459217-07-3 2-(1,3-diethyl-2-oxo-2,3-dihydro-1H-benzoimidazol-5-yl)-4-pyridin-3-yl-1-m-tolyl-butane-1,4-dione 
• 857663-88-8 2-(2-oxo-2-pyridin-3-yl-ethyl)-malononitrile 
• 944937-03-5 C₁₆H₁₈N₂O₂ 
• 118838-57-6 (1-R)-2-bromo-1-(3-pyridinyl)-1-ethanol 
• 800402-00-0 2-(2-oxo-2-pyridin-3-yl-ethyl)-isoindole-1,3-dione 
• 1018688-18-0 C₁₅H₉Cl₃N₄S 
• 1256944-06-5 5-((5-(4-chlorophenyl)furan-2-yl)methylene)-3-(2-oxo-2-(pyridin-3-yl)ethyl)thiazolidine-2,4-dione 
• 1234798-38-9 N-(5-(4-methyl-1H-imidazol-1-yl)-3-(trifluoromethyl)-phenyl)-4-methyl-3-(4-pyridin-3-yl-thiazol-2-ylamino)-benzamide 
• 1234798-39-0 N-(5-(1H-imidazol-1-yl)-3-(trifluoromethyl)-phenyl)-4-methyl-3-(4-pyridin-3-yl-thiazol-2-ylamino)-benzamide 

Relevant articles and documents

Antiangiogenic and growth inhibitory effects of synthetic novel 1, 5-diphenyl-1,4 pentadiene-3-one-3-yl-ethanone pyridine curcumin analogues on Ehrlich ascites tumor in vivo

In the present investigation we have synthesized novel substituted dienone pyridine ethanone curcumin analogues 3a and 3b by nucleophilic substitution reactions with 2-bromo-1-pyridine-3-yl ethanone and characterized by 1H nuclear magnetic reso

Design, synthesis, and biological evaluation of urea-based ROCK2 inhibitors

A series of urea-based ROCK2 inhibitors were design and synthesized. The inhibitory activity on ROCK2 was screened by enzyme-linked immunosorbent assay (ELISA). The study results showed that the urea derivatives exhibited certain ROCK2 inhibitory activity. The most potent compound 10p showed ROCK2 inhibitory activity with the IC50?value of 0.03?μM. A preliminary structure-activity relationship was then summarized. The molecular docking studies showed that further optimization needs to conduct to obtain more potent ROCK inhibitors.

DYEING COMPOSITION, DYED PRODUCT, AND AZO COLORING AGENT

Provided are a dyeing composition which contains an azo coloring agent represented by Formula 1 or 2, a dyed product which is obtained by being dyed with the dyeing composition, and a novel azo coloring agent. In Formulae 1 and 2, C1 represents a heteroaromatic group, A1 and B1 each independently represent a heteroaromatic group, an aromatic group, or a group having a methine structure, and at least one of A1 or B1 represents a heteroaromatic group, D1 represents an anthraquinonyl group, and E1 represents a heteroaromatic group, an aromatic group, or a group having a methine structure. [in-line-formulae]A1-N═N—C1—N═N—B1??Formula 1[/in-line-formulae] [in-line-formulae]D1-N═N-E1??Formula 2[/in-line-formulae]

COMPOUNDS FOR THE MODULATION OF MYC ACTIVITY

The present invention provides novel compounds of Formula (I) and pharmaceutically acceptable salts, solvates, hydrates, tautomers, stereoisomers, isotopically labeled derivatives, and compositions thereof. Also provided are methods and kits involving the compounds or compositions for treating or preventing proliferative diseases, e.g., cancers (e.g., breast cancer, prostate cancer, lymphoma, lung cancer, pancreatic cancer, ovarian cancer, neuroblastoma, or colorectal cancer), benign neoplasms, angiogenesis, inflammatory diseases, fibrosis (e.g., polycystic kidney disease), autoinflammatory diseases, and autoimmune diseases in a subject.