461426-34-6

Basic information

• Product Name: N-(4-Aminobenzoyl-d4)-L-glutamic Acid
• Synonyms: N-(4-Aminobenzoyl-d4)-L-glutamic Acid;N-(p-AMinobenzoyl-d4)glutaMic Acid;N-(p-AMinobenzoyl-d4)-L(+)-glutaMic Acid;NSC 71042-d4
• CAS NO: 461426-34-6
• Molecular Formula: C₁₂H₁₄N₂O₅
• Molecular Weight: 270.274607112
• Product Categories: Amino Acids & Derivatives;Isotope Labelled Compounds;Metabolites & Impurities
• Mol File: 461426-34-6.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: DMSO (Slightly), Methanol (Slightly)
• CAS DataBase Reference: N-(4-Aminobenzoyl-d4)-L-glutamic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Aminobenzoyl-d4)-L-glutamic Acid(461426-34-6)
• EPA Substance Registry System: N-(4-Aminobenzoyl-d4)-L-glutamic Acid(461426-34-6)

Safety Data

• Hazardous Substances Data: 461426-34-6(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

Labelled metabolite of 5-Methyltetrahydrofolic Acid

Upstream product

• 150-13-0 4-amino-benzoic acid 
• 461426-32-4 trifluoroacetyl-[2H₄]4-aminobenzoic acid 
• 350820-01-8 4-aminobenzoic-2,3,5,6-d₄ acid 
• 6525-53-7 L-glutamic acid dimethyl ester 
• 461426-33-5 trifluoroacetyl-[2H₄]4-aminobenzoylglutamate dimethylester 

Downstream Products

• 461426-36-8 N²-acetyl[2H₄]folic acid 
• 171777-72-3 <2',3',5',6'-2H4>folic acid 

Relevant articles and documents

Syntheses of labeled vitamers of folic acid to be used as internal standards in stable isotope dilution assays

[2H4]Folic acid was synthesized by deuterating p-aminobenzoic acid, which was then coupled to glutamic acid and 6-formylpterin, Using [2H4]folic acid as starting component enabled the preparation of labeled vitamers tetrahydrofolate, 5-formyltetrahydrofolate, 5-methyltetrahydrofolate, and 10-formylfolate which were characterized by electrospray mass spectrometry and collision-induced dissociation. The mass spectrometric studies confirmed that the compounds could be used as internal standards in stable isotope dilution assays.