461696-74-2Relevant articles and documents
Diastereoselective Synthesis of ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-Type Dipeptide Isosteres by Organocopper-mediated anti-SN2′ Reaction
Oishi, Shinya,Kamano, Takae,Niida, Ayumu,Odagaki, Yoshihiko,Tamamura, Hirokazu,Otaka, Akira,Hamanaka, Nobuyuki,Fujii, Nobutaka
, p. 1051 - 1054 (2007/10/03)
matrix presented Acyclic ψ[(E)-CH=CMe]- and ψ[(Z)-CH=CMe]-type dipeptide isosteres were efficiently synthesized. In a key reaction, α-alkylation of γ-mesyloxy-β-methyl-α,β-unsaturated esters with organocyanocuprates in diethyl ether or tetrahydrofuran preferentially afforded the ψ[(E)-CH=CMe]- or ψ[(Z)-CH=CMe]-isomer, respectively, via anti-SN2′ mechanism.
