4676-51-1Relevant articles and documents
Cyanide-Coordination Effect on Photochemical Carbon-Skeleton Rearrangements of Alkyl Ligands Coordinated to Vitamin B12 Model Complexes
Murakami, Yukito,Hisaeda, Yoshio,Ozaki, Toshiaki,Ohno, Terubisa,Fan, Sheng-Di,Matsuda, Yoshihisa
, p. 839 - 842 (1988)
The cyanide ion induced the heterolytic cleavage of the cobalt-carbon bond involved in vitamin B12 model complexes by its coordination to the central cobalt atom and enhanced the carbon-skeleton rearrangements via formation of anionic intermedi
Preparation method and application of sacubitril intermediate
-
, (2021/07/17)
The invention discloses a preparation method and application of a sacubitril intermediate. The sacubitril intermediate disclosed by the invention is obtained by taking itaconic anhydride as a raw material, performing chiral reduction, esterification, selective hydrolysis and carboxyl activation, and finally conducting coupling with 4-biphenylacetic acid. The invention also provides a method for preparing sacubitril by using the sacubitril intermediate. The preparation method provided by the invention has the advantages of easily available raw materials, simple process, economy, environmental protection and the like, and is more suitable for industrial production compared with other routes.
METHOD FOR THE PRODUCTION OF METHYLSUCCINIC ACID AND THE ANHYDRIDE THEREOF FROM CITRIC ACID
-
Page/Page column 16, (2018/04/21)
A process for the preparation of methylsuccinic acid in any form, including its salts, its mono- and diester derivatives and the anhydride thereof, which comprises reacting citric acid or a derivative thereof in decarboxylation conditions, said process comprising (i) reacting citric acid or mono- and diester derivatives thereof in a non- aqueous solvent, specifically excluding alcohols, on a metallic catalyst at a temperature between 50 to 400°C and under a partial hydrogen pressure from 0.1 to 50 bar or (ii) reacting citric acid or any salt thereof or mono-, di- and triester derivatives thereof on a metallic catalyst in solvents comprising at least 5% water, at a temperature of from 50 to 400°C under a hydrogen partial pressure from 0.1 to 400 bar
PROCESS FOR DOUBLE CARBONYLATION OF ALLYL ALCOHOLS TO CORRESPONDING DIESTERS
-
Paragraph 0064; 0067; 0068, (2017/07/14)
The invention relates to a process for doubly carbonylating allyl alcohols to the corresponding diesters, wherein a linear or branched allyl alcohol is reacted with a linear or branched alkanol (alcohol) with supply of CO and in the presence of a catalytic system composed of a palladium complex and at least one organic phosphorus ligand and in the presence of a hydrogen halide selected from HCl, HBr and HI.