2938-98-9

Basic information

• Product Name: 2-methylbutane-1,4-diol
• Synonyms: 2-methylbutane-1,4-diol;1,4-Butanediol, 2-methyl-;2-Methyl-1,4-butanediol;2-methyl-4-butanediol;NSC 91489
• CAS NO: 2938-98-9
• Molecular Formula: C₅H₁₂O₂
• Molecular Weight: 104.14758
• EINECS: 220-925-5
• Mol File: 2938-98-9.mol
• Article Data: 59

Chemical Properties

• Melting Point: 50.86°C (estimate)
• Boiling Point: 126-127℃
• Flash Point: 98.9±13.0℃
• Appearance: /
• Density: 1.4497 g/cm3 (20 ºC)
• Vapor Pressure: 0.0392mmHg at 25°C
• Refractive Index: 1.45 (589.3 nm 18℃)
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly)
• PKA: 14.91±0.10(Predicted)
• Stability: Unstable in Aqueous Solution
• CAS DataBase Reference: 2-methylbutane-1,4-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methylbutane-1,4-diol(2938-98-9)
• EPA Substance Registry System: 2-methylbutane-1,4-diol(2938-98-9)

Safety Data

• Hazardous Substances Data: 2938-98-9(Hazardous Substances Data)

Usage

General Description

2-methylbutane-1,4-diol is a chemical compound with the molecular formula C5H12O2. It is also known as tetramethylene glycol or 2,3-dihydroxy-2-methylbutane. 2-methylbutane-1,4-diol is a colorless, odorless liquid at room temperature and is commonly used as a solvent and as a building block in the synthesis of other chemicals. It has two hydroxyl groups, making it a diol, and the methyl group is located on the second carbon atom in the chain. 2-methylbutane-1,4-diol is used in various industries, including pharmaceuticals, cosmetics, and chemical manufacturing. It is important to handle this chemical with care, as it can be hazardous if not properly managed.

InChI:InChI=1/C5H12O2/c1-5(4-7)2-3-6/h5-7H,2-4H2,1H3

Upstream product

• 54462-66-7 1,4-dibromo-2-methyl-butane 
• 21307-96-0 methyl 2-methylsuccinate 
• 90106-98-2 Bromomethyl-dimethyl-(2-methyl-allyloxy)-silane 
• 617-52-7 Dimethyl itakonate 
• 22644-27-5 (R)-methylsuccinic acid dimethyl ester 
• 3641-51-8 2-(R)-methylsuccinic acid 
• 594-51-4 2,3-dibromo-2-methylbutane 
• 4676-51-1 Diethyl 2-methylsuccinate 
• 53627-41-1 (E)-2-methyl but-2-ene-1,4-diol 
• 616-02-4 citraconic acid anhydride 
• 22122-36-7 3-methyl-5H-furan-2-one 
• 627-27-0 homoalylic alcohol 
• 201230-82-2 carbon monoxide 
• 4100-80-5 2-methylsuccinic anhydride 

Downstream Products

• 51814-03-0 1,4-diacetoxy-2-methyl-butane 
• 2938-98-9 (R)-2-methylbutane-1,4-diol 
• 64190-48-3 dihydro-4-methyl-2(3H)-furanone 
• 1679-47-6 3-methyltetrahydro-2-furanone 
• 95753-86-9 (R,S)-2-methylbutane-1,4-diol dibenzoate 
• 13423-15-9 3-methyltetrahydrofuran 
• 69498-29-9 (-)-(3R)-N-benzyl-3-methylpyrrolidine 
• 1392282-84-6 (3R)-N-tosyl-3-methylpyrrolidine 
• 69498-26-6 (S)-1-benzyl-3-methylpyrrolidine 
• 96240-08-3 N-benzyl-3-methylpyrrolidine 
• 1444103-55-2 4-methyl-2-(4-((S)-2-((R)-3-methylpyrrolidin-1-yl)propoxy)phenyl)-3-(3-(methylsulfonyl)phenyl)-2H-chromen-6-ol 

Relevant articles and documents

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MOF-derived hcp-Co nanoparticles encapsulated in ultrathin graphene for carboxylic acids hydrogenation to alcohols

Highly efficient conversion of carboxylic acids to valuable alcohols is a great challenge for easily corroded non-noble metal catalysts. Here, a series of few-layer graphene encapsulated metastable hexagonal closed-packed (hcp) Co nanoparticles were fabricated by reductive pyrolysis of metal-organic framework precursor. The sample pyrolyzed at 400 °C (hcp-Co@G400) presented outstanding performance and stability for converting a variety of functional carboxylic acids and its turnover frequency was one magnitude higher than that of conventional facc-centered cubic (fcc) Co catalysts. In situ DRIFTS spectroscopy of model reaction acetic acid hydrogenation and DFT calculation results confirm that carboxylic acid initially undergoes dehydroxylation to RCH2CO* followed by consecutive hydrogenation to RCH2CH2OH through RCH2COH*. Acetic acid prefers to vertically adsorb at hcp-Co (0 0 2) facet with a much lower adsorption energy than parallel adsorption at fcc-Co (1 1 1) surface, which plays a key role in decreasing the activation barrier of the rate-determining step of acetic acid dehydroxylation.

SULFONIMIDAMIDE COMPOUNDS AS INHIBITORS OF INTERLEUKIN-1 ACTIVITY

The present disclosure relates to novel sulfonimidamide compounds and related compounds and their use in treating a disorder responsive to modulation of cytokines such as IL-1β and IL-18, modulation of NLRP3 or inhibition of the activation of NLRP3 or related components of the inflammatory process. (I)

A Diaminopropane Diolefin Ru(0) Complex Catalyzes Hydrogenation and Dehydrogenation Reactions

New ruthenium (0) complexes with a cooperative diolefin diaminopropane (DAP) or the dehydrogenated iminopropenamide ligand (IPA) were synthesized for comparison with their diaminoethane (DAE)/ diazadiene (DAD) ruthenium analogues. These DAP/IPA complexes are efficient catalysts in dehydrogenation reactions of alkaline aqueous methanol which proceeds under mild conditions (T=70 °C) and of higher alcohols, forming the corresponding carbonate and carboxylates, respectively. The scope of the reaction includes an example of a 1,2-diol as model for biomass derived alcohols. Their catalytic applications are extended to the atom-efficient dehydrogenative coupling of alcohols and amines to amides. The reaction proceeds without any additives and is applicable to the synthesis of formamides from methanol. Moreover, DAP/IPA complexes catalyze the hydrogenation of a series of esters, lactone, ketone, activated olefin, aldehyde and imine substrates. The diaminopropane Ru catalyst exhibits higher activity compared to the dehydrogenated β-ketiminate (IPA) and previously studied DAD/DAE based catalysts. We present studies on their stoichiometric reactivity with relevance to their possible catalytic mechanisms and the isolation and full characterization of key reaction intermediates.