469-11-4 Usage
Description
Labdanolic acid, also known as ladanum, is a natural compound derived from the Cistus ladaniferis plant. It is a resinous substance with a complex chemical structure, characterized by its unique aroma and various biological properties.
Uses
Used in Pharmaceutical Industry:
Labdanolic acid is used as an anti-inflammatory agent for its ability to reduce inflammation and alleviate pain. It is commonly found in traditional remedies and herbal formulations for treating various inflammatory conditions.
Used in Cosmetics Industry:
Labdanolic acid is used as a natural ingredient in cosmetics and personal care products for its soothing and moisturizing properties. It is often incorporated into creams, lotions, and balms to provide skin hydration and promote skin health.
Used in Perfumery Industry:
Due to its distinctive and pleasant aroma, labdanolic acid is used as a fixative and fragrance component in the perfumery industry. It helps to enhance and prolong the scent of perfumes and colognes.
Used in Traditional Medicine:
Labdanolic acid has been used in traditional medicine for centuries, particularly in Mediterranean and Middle Eastern cultures, for its healing properties. It is employed in various formulations to treat wounds, burns, and skin irritations.
Check Digit Verification of cas no
The CAS Registry Mumber 469-11-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,6 and 9 respectively; the second part has 2 digits, 1 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 469-11:
(5*4)+(4*6)+(3*9)+(2*1)+(1*1)=74
74 % 10 = 4
So 469-11-4 is a valid CAS Registry Number.
469-11-4Relevant articles and documents
Evaluation of labdane derivatives as potential anti-inflammatory agents
Girón, Natalia,Pérez-Sacau, Elisa,López-Fontal, Raquel,Amaro-Luis, Juan M.,Hortelano, Sonsoles,Estevez-Braun, Ana,De Las Heras, Beatriz
experimental part, p. 3155 - 3161 (2010/08/22)
In the present study, a series of labdane derivatives (2-9) were prepared from labdanediol (1) and their potential as anti-inflammatory agents were evaluated on lipopolysaccharide (LPS)-treated RAW 264.7 macrophages. All compounds were able to inhibit LPS-induced nitric oxide (NO), although compounds 1, 2, 5, 8 and 9 exhibited the most potent effects with a range of IC 50 values of 5e15 mM. Similarly to the inhibitory effects on NO release, these labdane derivatives also inhibited prostaglandin E2 (PGE 2) production. However, analysis of cell viability demonstrated that effects on NO release and (PGE2) production of compounds 1, 8 and 9 were due to citotoxicity, whereas compound 2 and 5 did not show any effect in the survival of RAW 264.7 macrophages. In addition to these in vitro data, compound 5 also showed anti-inflammatory activity in vivo, when tested in mice. They prevented the extent of swelling in the TPA-induced ear edema model and inhibited MPO activity, showing similar potency to that of the widely used anti-inflammatory drug indomethacin. These results indicate that compound 2 and in particular compound 5 might be used for the design of new anti-inflammatory agents.
Stereoselective total synthesis of (±)-eperuane-8 β,15-diol and (±)-labdane-8 α,15-diol
Nakamura,Hirota,Takahashi
, p. 3518 - 3521 (2007/10/02)
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