471903-41-0

Basic information

• Product Name: Cyclohexanol, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, trans-
• CAS NO: 471903-41-0
• Molecular Formula: C18H17ClF2O3S
• Molecular Weight: 386.847
• Mol File: 471903-41-0.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Cyclohexanol, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, trans-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanol, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, trans-(471903-41-0)
• EPA Substance Registry System: Cyclohexanol, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, trans-(471903-41-0)

Safety Data

• Hazardous Substances Data: 471903-41-0(Hazardous Substances Data)

Upstream product

• 85117-99-3 2-(bromomethyl)-1,4-difluorobenzene 
• 471903-19-2 5-(4-chloro-benzenesulfonyl)-5-(2,5-difluoro-phenyl)-2-hydroxy-cyclohex-1-enecarboxylic acid methyl ester 
• 470716-51-9 2-[[(4-chlorophenyl)sulfonyl]methyl]-1,4-difluorobenzene 
• 470716-52-0 2-[[(4-chlorophenyl)thio]methyl]-1,4-difluorobenzene 
• 106-54-7 p-Chlorothiophenol 
• 852312-96-0 5-(4-chloro-benzenesulfonyl)-5-(2,5-difluoro-phenyl)-2-oxo-cyclohexanecarboxylic acid methyl ester 
• 471903-20-5 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanone 

Downstream Products

• 471903-56-7 methanesulfonic acid 4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexyl ester 
• 471904-46-8 C₁₉H₁₈ClF₂NO₃S 
• 677772-84-8 MRK-560 
• 471903-64-7 methanesulfonic acid 4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexylmethyl ester 
• 471904-45-7 4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexanecarboxylic acid 
• 471905-10-9 [4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexyl]-methanol 
• 471903-58-9 4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexylamine 
• 471903-57-8 2-[4-Azido-1-(4-chloro-benzenesulfonyl)-cyclohexyl]-1,4-difluoro-benzene 
• 471904-44-6 4-(4-chloro-benzenesulfonyl)-4-(2,5-difluoro-phenyl)-cyclohexanecarbonitrile 

Relevant articles and documents

4-Substituted cyclohexyl sulfones as potent, orally active γ-secretase inhibitors

The protease γ-secretase plays a pivotal role in the synthesis of pathogenic amyloid-β in Alzheimer's disease (AD). Here, we report a further extension to a series of cyclohexyl sulfone-based γ-secretase inhibitors which has allowed the preparation of hig

CYCLOHEXYL SULPHONES FOR TREATMENT OF CANCER

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The new cyclohexylpropionic sulfone

Novel sulphones of formula I are disclosed: The compounds modulate the processing of amyloid precursor protein by gamma-secretase, and hence are useful in the treatment or prevention of Alzheimer's disease.