473257-46-4Relevant articles and documents
Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing
Zhao, Tong,Meng, Qing,Kang, Dongwei,Ji, Jianbo,De Clercq, Erik,Pannecouque, Christophe,Liu, Xinyong,Zhan, Peng
, (2019)
For more in-depth exploration of the chemical space around the entrance channel of HIV-1 reverse transcriptase (RT), a series of novel indolylarylsulfones (IASs) bearing different chiral N-substituted pyrrolidine, azetidine or substituted sulfonamide grou
Indole aryl sulfone derivative containing boric acid as well as preparation method and application thereof
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, (2021/06/09)
The invention provides an indole aryl sulfone derivative containing boric acid. The indole aryl sulfone derivative has a structure as shown in general formulas I, II or III. The invention also relates to a preparation method of the derivative and applicat
Discovery of novel piperidine-substituted indolylarylsulfones as potent HIV NNRTIs via structure-guided scaffold morphing and fragment rearrangement
Li, Xiao,Gao, Ping,Huang, Boshi,Zhou, Zhongxia,Yu, Zhao,Yuan, Zheng,Liu, Huiqing,Pannecouque, Christophe,Daelemans, Dirk,De Clercq, Erik,Zhan, Peng,Liu, Xinyong
, p. 190 - 201 (2016/10/25)
To further explore the chemical space around the entrance channel of HIV-1 reverse transcriptase (RT), a series of novel indolylarylsulfones (IASs) bearing N-substituted piperidine at indole-2-carboxamide were identified as potent HIV NNRTIs by structure-