473278-50-1

Basic information

• Product Name: Silane, methylenebis[chlorobis(1-methylethyl)-
• Synonyms: bis(diisopropylchlorosilyl)methane;2-{Chloro-[(chloro-diisopropyl-silanyl)-methyl]-isopropyl-silanyl}-propane;methylene-bis(diisopropylsilyl chloride)
• CAS NO: 473278-50-1
• Molecular Formula: C13H30Cl2Si2
• Molecular Weight: 313.458
• Mol File: 473278-50-1.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Silane, methylenebis[chlorobis(1-methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, methylenebis[chlorobis(1-methylethyl)-(473278-50-1)
• EPA Substance Registry System: Silane, methylenebis[chlorobis(1-methylethyl)-(473278-50-1)

Safety Data

• Hazardous Substances Data: 473278-50-1(Hazardous Substances Data)

Usage

General Description

Silane, methylenebis[chlorobis(1-methylethyl)- is a chemical compound that is also known by its systematic name, 1,1'-methylenebis(4-isopropylbenzene). It is a silane coupling agent used in various industrial applications, including as a surface modifier and adhesion promoter in the production of polymers and composite materials. This chemical is a clear, colorless liquid with a mild odor and is classified as a hazardous substance due to its flammability and potential for causing irritation to the skin, eyes, and respiratory system. It is important to handle and store this chemical with care and follow safety precautions to minimize the risk of exposure and accidents.

Upstream product

• 56-23-5 tetrachloromethane 
• 473278-51-2 bis(diisopropylsilyl)methane 
• 67-66-3 chloroform 

Downstream Products

• 1363774-51-9 3',5'-O-(methylene-bis-diisopropylsilane-1,3-diyl)-2'-O-(ethoxycarbonylmethyl)inosine 
• 1363774-50-8 3',5'-O-(methylene-bis-diisopropylsilane-1,3-diyl)-2'-O-(ethoxycarbonylmethyl)-N,N-dimethyladenosine 
• 1363774-45-1 3',5'-O-(methylene-bis-diisopropylsilane-1,3-diyl)-2'-O-(methoxycarbonylmethyl)-6-chloropurine riboside 
• 1363774-44-0 3',5'-O-(methylene-bis-diisopropylsilane-1,3-diyl)-2'-O-(methoxycarbonylmethyl)-N,N-dimethyladenosine 
• 1363774-42-8 3',5'-O-(methylene-bis-diisopropylsilane-1,3-diyl)-6-chloropurine riboside 
• 572912-50-6 2-Amino-9-((2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-methoxy-hexahydro-1,4,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl)-1,9-dihydro-purin-6-one 
• 473278-53-4 2-Amino-9-[(2R,3R,3aR,9aR)-5,5,7,7-tetraisopropyl-3-(2-methoxy-ethoxy)-hexahydro-1,4,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl]-1,9-dihydro-purin-6-one 
• 473278-52-3 2-Amino-9-((2R,3R,3aS,9aR)-3-hydroxy-5,5,7,7-tetraisopropyl-hexahydro-1,4,8-trioxa-5,7-disila-cyclopentacycloocten-2-yl)-1,9-dihydro-purin-6-one 

Relevant articles and documents

NEW METHODS FOR THE PREPARATION OF TAXANES USING CHIRAL AUXILIARIES

The present invention relates to a stereoselective synthesis of novel β-lactam dimers as useful precursors for the preparation of paclitaxel, docetaxel, and analogues thereof. More particularly, the new β-lactams are prepared from readily available and enantiomerically pure chiral auxiliaries. The β-lactams are then reacted with a suitably protected taxane to produce diastereomerically enriched side chain-bearing taxanes. Finally, the chiral auxiliary is cleaved and protecting groups are removed to provide the desired taxane.

Synthesis of 2'-O-methoxyethylguanosine using a novel silicon-based protecting group.

A short and efficient synthesis of 2'-O-methoxyethylguanosine (8) is described. Central to this strategy is the development of a novel silicon-based protecting group (MDPSCl(2), 2) used to protect the 3',5'-hydroxyl groups of the ribose. Silylation of guanosine with 2 proceeded with excellent regioselectivity and in 79% yield. Alkylation of the 2'-hydroxyl group of 6 proceeded with methoxyethyl bromide and NaHMDS and afforded compound 7 in 85% yield, without any noticeable cleavage of the silyl protecting group and without the need to protect the guanine base moiety. Finally, deprotection of 7 was achieved using TBAF and produced 8 in 97% yield.