572912-50-6

Basic information

• Product Name: Guanosine, 2'-O-methyl-3',5'-O-[methylenebis[bis(1-methylethyl)silylene]]-
• CAS NO: 572912-50-6
• Molecular Formula: C24H43N5O5Si2
• Molecular Weight: 537.807
• Mol File: 572912-50-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Guanosine, 2'-O-methyl-3',5'-O-[methylenebis[bis(1-methylethyl)silylene]]-(CAS DataBase Reference)
• NIST Chemistry Reference: Guanosine, 2'-O-methyl-3',5'-O-[methylenebis[bis(1-methylethyl)silylene]]-(572912-50-6)
• EPA Substance Registry System: Guanosine, 2'-O-methyl-3',5'-O-[methylenebis[bis(1-methylethyl)silylene]]-(572912-50-6)

Safety Data

• Hazardous Substances Data: 572912-50-6(Hazardous Substances Data)

Upstream product

• 473278-50-1 methylene-bis(diisopropylsilyl chloride) 

Downstream Products

• 2140-71-8 2'-O-methylguanosine 

Relevant articles and documents

MDPSCL2: a new protecting group for chemoselective synthesis of 2'-O-alkylated guanosines.

An improved strategy for the synthesis of 2'-O-methyl-guanosine (6) and 2'-MOE-guanosine (8) is reported. The regioselectivity of the alkylation was attained using a novel silicon-based protecting group, methylene-bis (diisopropyl-silylchloride) (MDPSCl2, 2). The alkylation proceeded in a chemoselective manner using NaHMDS as the base and MeCl or MOE-Br as the appropriate electrophiles.