474417-78-2

Basic information

• Product Name: benzyl (2S)-N-tert-butoxycarbonyl-4-difluoromethyleneprolinate
• Synonyms: benzyl (2S)-N-tert-butoxycarbonyl-4-difluoromethyleneprolinate
• CAS NO: 474417-78-2
• Molecular Weight: 353.366
• Mol File: 474417-78-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: benzyl (2S)-N-tert-butoxycarbonyl-4-difluoromethyleneprolinate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl (2S)-N-tert-butoxycarbonyl-4-difluoromethyleneprolinate(474417-78-2)
• EPA Substance Registry System: benzyl (2S)-N-tert-butoxycarbonyl-4-difluoromethyleneprolinate(474417-78-2)

Safety Data

• Hazardous Substances Data: 474417-78-2(Hazardous Substances Data)

Upstream product

• 75-61-6 dibromodifluoromethane 
• 154456-97-0 2-benzyl 1-(tert-butyl) (S)-4-oxopyrrolidine-1,2-dicarboxylate 
• 51-35-4 4R-4-hydroxyproline 
• 89813-47-8 N-(tert-butoxycarbonyl)-(2S,4R)-4-hydroxyproline benzyl ester 
• 13726-69-7 (2S,4R)-4-hydroxy-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine-2-carboxylic acid 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 474417-79-3 (2S,4S)-N-tert-butoxycarbonyl-4-difluoromethylproline 

Relevant articles and documents

Practical synthesis of Boc-protected cis-4-trifluoromethyl and cis-4-difluoromethyl-L- prolines

A short, efficient, and diastereomerically pure synthesis of N-Boc-cis-4-trifluoromethyl-L-proline (7) and N-Boc-cis-4-difluoromethyl-L-proline (9) from N-Boc-4-oxo- L-proline (4) is described. The reaction of 4 with Me3SiCF3 and the conversion of the carbonyl group of 4 into the difluoromethylene group are the key steps for the synthesis of 7 and 9, respectively.