474417-79-3 Usage
Description
(2S,4S)-N-tert-butoxycarbonyl-4-difluoromethylproline is a chemical compound derived from the naturally occurring proline amino acid. It features a tert-butoxycarbonyl (Boc) protecting group and a difluoromethyl (CF2H) substituent, which are located at the 4th and 5th positions, respectively. This modified form of proline is utilized in organic synthesis and medicinal chemistry research, offering a protected amine moiety and an enhanced biological activity or altered physical properties due to the difluoromethyl substituent. It serves as a valuable building block for the synthesis of complex molecules and holds potential in drug discovery and development.
Uses
Used in Organic Synthesis:
(2S,4S)-N-tert-butoxycarbonyl-4-difluoromethylproline is used as a building block for the synthesis of complex organic molecules. The Boc protecting group allows for selective reactions with other functional groups, making it a versatile component in the creation of intricate molecular structures.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (2S,4S)-N-tert-butoxycarbonyl-4-difluoromethylproline is employed as a key intermediate in the development of new pharmaceutical compounds. The difluoromethyl substituent can improve the biological activity of the synthesized molecules, potentially leading to more effective drugs.
Used in Drug Discovery and Development:
(2S,4S)-N-tert-butoxycarbonyl-4-difluoromethylproline is utilized as a starting material in drug discovery and development processes. Its unique structure and properties make it a promising candidate for the creation of novel therapeutic agents with improved efficacy and selectivity.
Check Digit Verification of cas no
The CAS Registry Mumber 474417-79-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,4,4,1 and 7 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 474417-79:
(8*4)+(7*7)+(6*4)+(5*4)+(4*1)+(3*7)+(2*7)+(1*9)=173
173 % 10 = 3
So 474417-79-3 is a valid CAS Registry Number.
474417-79-3Relevant articles and documents
Practical synthesis of Boc-protected cis-4-trifluoromethyl and cis-4-difluoromethyl-L- prolines
Qiu, Xiao-long,Qing, Feng-ling
, p. 7162 - 7164 (2002)
A short, efficient, and diastereomerically pure synthesis of N-Boc-cis-4-trifluoromethyl-L-proline (7) and N-Boc-cis-4-difluoromethyl-L-proline (9) from N-Boc-4-oxo- L-proline (4) is described. The reaction of 4 with Me3SiCF3 and the conversion of the carbonyl group of 4 into the difluoromethylene group are the key steps for the synthesis of 7 and 9, respectively.
