474944-16-6 Usage
Description
1,2-dipalMitoyl-sn-glycero-3-phosphoethanolaMine-N-[3-(2-pyridyldithio)propionate] (sodium salt) is a paramagnetic pH-sensitive liposome that serves as an imaging tool for visualizing drug-delivery and release processes through magnetic resonance imaging (MRI).
Used in Pharmaceutical Industry:
1,2-dipalMitoyl-sn-glycero-3-phosphoethanolaMine-N-[3-(2-pyridyldithio)propionate] (sodium salt) is used as a component in the preparation of rhodamine high-density lipoprotein nanoparticles (Rh-HDL NP) for targeted drug delivery and imaging purposes.
Used in Nanotechnology:
1,2-dipalMitoyl-sn-glycero-3-phosphoethanolaMine-N-[3-(2-pyridyldithio)propionate] (sodium salt) is used as a building block in the synthesis of high-density lipoprotein (HDL)-like nanoparticles, which have potential applications in drug delivery, diagnostics, and therapeutics.
Check Digit Verification of cas no
The CAS Registry Mumber 474944-16-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,7,4,9,4 and 4 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 474944-16:
(8*4)+(7*7)+(6*4)+(5*9)+(4*4)+(3*4)+(2*1)+(1*6)=186
186 % 10 = 6
So 474944-16-6 is a valid CAS Registry Number.
474944-16-6Relevant articles and documents
Sorting of lipidated peptides in fluid bilayers: A molecular-level investigation
Daly, Trevor A.,Almeida, Paulo F.,Regen, Steven L.
, p. 17245 - 17252 (2012)
Nearest-neighbor recognition (NNR) measurements have been made for two lipidated forms of GlyCys, interacting with analogues of cholesterol and 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in the liquid-ordered (l o) and liquid-disordered (ld) phases. Interaction free energies that have been determined from these measurements have been used in Monte Carlo simulations to quantify the distribution of the peptides between liquid-ordered and liquid-disordered regions. These simulations have shown that significant differences in the lipid chains have a very weak influence on the partitioning of the peptide between these two phases. They have also revealed an insensitivity of the peptide partition coefficient, Kp, to the size of the lo and ld domains that are present. In a broader context, these findings strongly suggest that the sorting of peripheral proteins in cellular membranes via differential lipidation may be more subtle than previously thought.
