923-61-5 Usage
Description
1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine, also known as 1,2-Dipalmitoyl-sn-glycero-3-phosphatidylethanolamine (1,2-DPPE), is a naturally occurring phospholipid containing C16:0 fatty acids at the sn-1 and sn-2 positions. It is an aminophospholipid that is present in both eukaryotic and prokaryotic cells and is one of the most abundant glycerophospholipids in biological membranes, particularly in nervous tissue. 1,2-DPPE plays a crucial role in the formation of a condensed lipid monolayer with cholesterol, resulting in a more fluid membrane that aids in transport and signaling across the bilayer.
Uses
1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine is used in various applications across different industries, including:
Used in Model Membranes:
1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine is used as a component in model membrane systems for studying the properties and behavior of biological membranes, as well as for understanding the interactions between lipids and other membrane components.
Used in Perfluorocarbon (PFC) Nanoparticles Preparation:
In the pharmaceutical industry, 1,2-DPPE is used as a lipid component for the preparation of perfluorocarbon nanoparticles. These nanoparticles have potential applications in drug delivery, imaging, and oxygen transport.
Used in Liposome Floatation Assays:
1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine is used as a lipid binding agent in liposome flotation assays. This application is crucial for determining the lipid-binding properties of various molecules, which can be important for drug development and understanding the mechanisms of action.
Used in Characterizing Metabolic Fate of Synaptamide in Dopaminergic Cell Lines:
In the field of neuroscience, 1,2-DPPE is used to characterize the metabolic fate of synaptamide in dopaminergic cell lines. This helps researchers understand the role of synaptamide in neuronal function and its potential involvement in neurodegenerative diseases.
1,2-Dipalmitoyl-sn-glycero-3-PE MaxSpec Standard:
A quantitative grade standard of 1,2-dipalmitoyl-sn-glycero-3-PE is available, specifically prepared for mass spectrometry and related applications where quantitative reproducibility is required. This standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product.
Biochem/physiol Actions
1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine is a phospholipid, a lipid component in cell membrane .
Check Digit Verification of cas no
The CAS Registry Mumber 923-61-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,2 and 3 respectively; the second part has 2 digits, 6 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 923-61:
(5*9)+(4*2)+(3*3)+(2*6)+(1*1)=75
75 % 10 = 5
So 923-61-5 is a valid CAS Registry Number.
923-61-5Relevant articles and documents
1,2-dipalmitoyl-SN-glycerol-3-phosphoethanolamine and preparation method thereof
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Paragraph 0048; 0073-0085, (2019/10/23)
The invention provides 1,2-dipalmitoyl-SN-glycerol-3-phosphoethanolamine and a preparation method thereof. The preparation method comprises the following steps: S1, performing a nucleophilic substitution reaction on glyceryldipalmitate and POCl3 under the action of tetrahydrofuran and alkali, and purifying a reaction product after completion of the reaction to obtain an intermediate 1, wherein theintermediate 1 is (R)-3-((dichlorophosphoryl)oxy)propane-1,2-dipalmitic acid; S2, performing a nucleophilic substitution reaction on the intermediate 1 and N-Fmoc-ethanolamine under the action of tetrahydrofuran and alkali, and purifying a reaction product after completion of the reaction to obtain an intermediate 2, wherein the intermediate 2 is (R)-3-(((2-( fluorenylmethoxy carbonylamino)ethoxy)(hydroxy)phosphoryl)oxy)propane-1,2-dipalmitate; and S3, performing a nucleophilic substitution reaction on the intermediate 2 under the action of a solvent and alkali to obtain the 1,2-dipalmitoyl-SN-glycerol-3-phosphoethanolamine. According to the preparation method provided by the embodiment of the invention, a final product is relatively high in purity, and byproducts are few.
Chelating agents with lipophilic carriers
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, (2008/06/13)
Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components.
Method of lowering the viscosity of mucus
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, (2008/06/13)
The use of phospholipids of the following formula to reduce the viscosity of mucus in a patient is described: STR1 wherein one of X, Y, or Z represent: STR2 in which each R represents hydrogen or methyl, and each of the other two of X, Y, or Z represents --CO--R1 in which R1 represents linear or branched C11-21 alkyl or C11-21 alkenyl, unsubstituted or substituted with one or more substituents selected from the group consisting of halo, C1-6 linear or branched alkoxy or cyano.
