80749-31-1

Basic information

• Product Name: N-trityl-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine
• Synonyms: N-trityl-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine
• CAS NO: 80749-31-1
• Molecular Weight: 934.29
• Mol File: 80749-31-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-trityl-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-trityl-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine(80749-31-1)
• EPA Substance Registry System: N-trityl-1,2-Dipalmitoyl-sn-glycero-3-phosphoethanolamine(80749-31-1)

Safety Data

• Hazardous Substances Data: 80749-31-1(Hazardous Substances Data)

Upstream product

• 923-61-5 1,2-dipalmitoyl-3-sn-phosphatidylethanolamine 
• 596-43-0 bromo-triphenyl-methane 
• 30334-71-5 1,2-dipalmitoyl-sn-glycerol 
• 496808-59-4 Hexadecanoic acid (R)-2-(diisopropylamino-methoxy-phosphanyloxy)-1-hexadecanoyloxymethyl-ethyl ester 
• 24070-16-4 N-tritylethanolamine 
• 102152-58-9 Hexadecanoic acid (R)-1-hexadecanoyloxymethyl-2-{methoxy-[2-(trityl-amino)-ethoxy]-phosphoryloxy}-ethyl ester 

Downstream Products

• 923-61-5 1,2-dipalmitoyl-3-sn-phosphatidylethanolamine 

Relevant articles and documents

A Simple and Efficient Method for Synthesis of sn-Glycero-Phosphoethanolamine

An efficient three-step strategy for the convenient synthesis of Sn-glycero-3-phosphoethanolamine (GroPEtn) from a commercially available 1,2-dipalmitoyl-sn-glycero-3-phosphoethanolamine (DPPE) is reported. Direct hydrolysis of DPPE produces a complex inseparable mixture, hence a protection and deprotection strategy is employed to prepare GroPEtn. The primary amine of DPPE is protected with a highly stable acid-labile trityl group, followed by strong base hydrolysis of N-trityl-DPPE gives N-trityl-GroPEtn. Further a mild, rapid, and efficient deprotection method is established using trifluoroacetic acid to remove N-trityl moiety, affords GroPEtn as a single product. This is the first semisynthetic approach and efficient method to produce GroPEtn with a total yield of 66% in three steps. GroPEtn did not show any cytotoxicity against human kidney (HK-2) cells and reporter gene assay for activation of Keap1-Nrf2-mediated antioxidant defense mechanism showed no significant effects.