475060-22-1

Basic information

• Product Name: tert-butyl N-(5-fluoro-4-methyl-pyridin-2-yl)carbamate
• CAS NO: 475060-22-1
• Molecular Weight: 226.251
• Mol File: 475060-22-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: tert-butyl N-(5-fluoro-4-methyl-pyridin-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N-(5-fluoro-4-methyl-pyridin-2-yl)carbamate(475060-22-1)
• EPA Substance Registry System: tert-butyl N-(5-fluoro-4-methyl-pyridin-2-yl)carbamate(475060-22-1)

Safety Data

• Hazardous Substances Data: 475060-22-1(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 475060-21-0 N₁-(5-fluoro-4-methyl-pyridin-2-yl)acetamide 
• 21901-40-6 2-amino-5-nitro-4-picoline 
• 301222-66-2 2-amino-5-fluoro-4-methylpyridine 
• 90765-02-9 N-(4-methyl-5-nitropyridin-2-yl) acetamide 
• 475060-18-5 N₁-(5-amino-4-methyl-pyridin-2-yl)acetamide 

Relevant articles and documents

MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 4: Addressing the problem of poor stability due to photoisomerization of an acrylic acid moiety

Exchange of the ethylene tether in a series of pyridopyrimidine-based MexAB-OprM specific efflux pump inhibitors to an amide bond stabilized the olefin of the acrylic acid moiety, preventing facile photoisomerization to the Z-isomer. Furthermore, the activity was drastically improved in the amide tether variants, providing extremely potent acrylic acid and vinyl tetrazole analogues.