475232-29-2

Basic information

• Product Name: 3-hydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano[4',3':4,5]-pyrrolo[2,1-a]isoquinolin-6-one
• Synonyms: 3-hydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano[4',3':4,5]-pyrrolo[2,1-a]isoquinolin-6-one
• CAS NO: 475232-29-2
• Molecular Weight: 513.504
• Mol File: 475232-29-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3-hydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano[4',3':4,5]-pyrrolo[2,1-a]isoquinolin-6-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano[4',3':4,5]-pyrrolo[2,1-a]isoquinolin-6-one(475232-29-2)
• EPA Substance Registry System: 3-hydroxy-14-(3-hydroxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano[4',3':4,5]-pyrrolo[2,1-a]isoquinolin-6-one(475232-29-2)

Safety Data

• Hazardous Substances Data: 475232-29-2(Hazardous Substances Data)

Upstream product

• 1225441-64-4 3-hydroxy-2,11,12-trimethoxy-14-[4-methoxy-3-(methoxymethoxy)phenyl]-6H-[1]benzopyrano[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 
• 475232-32-7 3-isopropoxy-14-(3-isopropoxy-4-methoxyphenyl)-2,11,12-trimethoxy-6H-[1]benzopyrano-[4',3':4,5]pyrrolo[2,1-a]isoquinolin-6-one 
• 121-33-5 vanillin 
• 1192217-74-5 7-isopropoxy-8-methoxy[1]benzopyrano[3,4-b]pyrrol-4(3H)-one 
• 623550-16-3 4-bromo-1-methoxy-2-(methoxymethoxy)benzene 
• 570402-54-9 dimethyl 1-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-bis(trifluoromethanesulfonyloxy)pyrrole-2,5-dicarboxylate 
• 570402-52-7 dimethyl 3,4-dihydroxy-1-[2-(3,4-dimethoxyphenyl)ethyl]pyrrole-2,5-dicarboxylate 
• 570402-50-5 dimethyl N-[2-(3,4-dimethoxyphenyl)ethyl]iminodiacetate 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 37942-01-1 5-bromo-2-methoxyphenol 
• 40914-19-0 3-benzyloxy-4-methoxyphenol 
• 1352336-46-9 2-[4-methoxy-3-(methoxymethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 540463-56-7 2-benzyloxy-1-methoxy-4-(methoxymethoxy)benzene 

Relevant articles and documents

Synthesis of lamellarins via regioselective assembly of 1,2-diarylated [1]benzopyrano[3,4-b]pyrrol-4(3H)-one core

A modular synthesis of lamellarins has been developed. The key reactions in this synthesis are the assembly of 1,2-diarylated [1]benzopyrano- [3,4-b]pyrrol-4(3H)-ones from a preexisting [1]benzopyrano[3,4-b]pyrrol- 4(3H)-one core and the appropriate arylb

Divergent synthesis of lamellarin α 13-sulfate, 20-sulfate, and 13,20-disulfate

A divergent synthesis of three sulfate derivatives of lamellarin α, namely, lamellarin α 13-sulfate (2), 20-sulfate (1), and 13,20-disulfate (4) has been achieved via a common intermediate (6) in which 13-OH and 20-OH of the lamellarin core are differentially protected by MOM and benzyl groups, respectively. Compound (6) in turn was prepared using sequential Suzuki-Miyaura coupling of 3,4-dihydroxypyrrole bistriflate (7) as a key reaction.

Total synthesis and evaluation of lamellarin α 20-Sulfate analogues

In order to explore the influence of sulfate groups on the bioactivity profiles of marine alkaloids of the lamellarin class, three such alkaloids, lamellarin α lamellarin α 13,20-disulfate and H, were synthesized and their activities against HIV-1 integrase and cancer cell ines were compared with those of lamellarin α 20-sulfate, which is a selective inhibitor of HIV-1 integrase. Lamellarin α does not inhibit HIV-1 integrase but shows moderate cytotoxicity with good cell line selectivity. Lamellarin α13,20-disulfate is a moderate inhibitor of both HIV-1 integrase and cancer cell lines. Lamellarin H is a more potent inhibitor of HIV-1 integrase but lacked the specificity required to be medicinally useful. Copyright