4767-31-1

Basic information

• Product Name: 2-biphenyl-4-yl-1-(diaminomethylidene)guanidine
• CAS NO: 4767-31-1
• Molecular Formula: C₁₄H₁₅N₅
• Molecular Weight: 253.3024
• Mol File: 4767-31-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 498.4°C at 760 mmHg
• Flash Point: 255.3°C
• Density: 1.26g/cm³
• Vapor Pressure: 4.53E-10mmHg at 25°C
• Refractive Index: 1.656
• CAS DataBase Reference: 2-biphenyl-4-yl-1-(diaminomethylidene)guanidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-biphenyl-4-yl-1-(diaminomethylidene)guanidine(4767-31-1)
• EPA Substance Registry System: 2-biphenyl-4-yl-1-(diaminomethylidene)guanidine(4767-31-1)

Safety Data

• Hazardous Substances Data: 4767-31-1(Hazardous Substances Data)

Upstream product

• 92-67-1 4-phenylalanine 
• 127099-85-8 N-Cyanoguanidine 

Relevant articles and documents

Identifying Lysophosphatidic Acid Acyltransferase β (LPAAT-β) as the Target of a Nanomolar Angiogenesis Inhibitor from a Phenotypic Screen Using the Polypharmacology Browser PPB2

By screening a focused library of kinase inhibitor analogues in a phenotypic co-culture assay for angiogenesis inhibition, we identified an aminotriazine that acts as a cytostatic nanomolar inhibitor. However, this aminotriazine was found to be completely inactive in a whole-kinome profiling assay. To decipher its mechanism of action, we used the online target prediction tool PPB2 (http://ppb2.gdb.tools), which suggested lysophosphatidic acid acyltransferase β (LPAAT-β) as a possible target for this aminotriazine as well as several analogues identified by structure–activity relationship profiling. LPAAT-β inhibition (IC50 ≈15 nm) was confirmed in a biochemical assay and by its effects on cell proliferation in comparison with a known LPAAT-β inhibitor. These experiments illustrate the value of target-prediction tools to guide target identification for phenotypic screening hits and significantly expand the rather limited pharmacology of LPAAT-β inhibitors.