477-57-6 Usage
Description
Isotetrandrine is a bisbenzylisoquinoline alkaloid, which is identical to berbamine methyl ether. It is found in various plant sources such as Atherosperma moschatum, Berberis japonica, and Stephania cephalantha. ISOTETRANDRINE is dextrorotatory with specific optical rotation values and forms colorless crystals when recrystallized from methanol. It is characterized by the presence of four methoxyl groups and two methylimino groups. Isotetrandrine is known for its inhibitory effects on G protein activation of phospholipase A2 (PLA2).
Uses
Used in Pharmaceutical Industry:
Isotetrandrine is used as a pharmaceutical agent for its inhibitory effects on G protein activation of PLA2. This property makes it a potential candidate for the development of drugs targeting various diseases and conditions related to PLA2 dysregulation.
Used in Research Applications:
In the field of research, isotetrandrine is used as a tool compound to study the role of G protein-coupled receptors and PLA2 in cellular signaling pathways. This helps researchers understand the underlying mechanisms of various diseases and develop targeted therapeutic strategies.
Used in Drug Development:
Isotetrandrine's ability to inhibit G protein activation of PLA2 makes it a valuable compound in the development of new drugs for conditions where PLA2 plays a significant role, such as inflammation, pain, and certain types of cancer.
References
Kondo et al., J. Pharrn. Soc., Japan, 58,920 (1938)Tomita, Fujita, Morai., ibid, 71,226,301 (1951)Bick, Clezy, Crow., Austral. J. Chern., 9, III (1956)Synthesis:Inubushi et ai., Tetrahedron Lett., 3399 (1968)
Check Digit Verification of cas no
The CAS Registry Mumber 477-57-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,7 and 7 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 477-57:
(5*4)+(4*7)+(3*7)+(2*5)+(1*7)=86
86 % 10 = 6
So 477-57-6 is a valid CAS Registry Number.
InChI:InChI=1/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30+/m1/s1
477-57-6Relevant articles and documents
Full-synthetic method of racemic tetrandrine
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, (2019/07/10)
The invention discloses a full-synthetic method of racemic tetrandrine, and belongs to the technical field of drug synthesis. The full-synthetic method of the racemic tetrandrine comprises the steps that a synthetic route adopts a convergence synthesis method, a 5-bromovanillin, namely a compound 1 and 3-hydroxy-4-methoxyphenylacetic acid, namely a compound 5 are taken as starting materials to obtain a compound 4 and a compound 6 respectively, then the compound 4 and the compound 6 are taken as raw materials to synthesize a compound 11, a compound 19 is synthesized from the compound 11, and finally, the compound 11 reacts with the compound 19. The full-synthetic method of the racemic tetrandrine has the advantages that the synthetic efficiency is higher, the yield is higher, and the cost is lower; the reaction conditions are milder, the operation is simple and convenient, the industrial value is higher, and a reference is provided for the full-synthetic method of optical voidness tetrandrine.
Alcaloides bisbenzylisoquinoleiques de Albertisia cf. A. papuana
Lavault, Marie,Bruneton, Jean,Cave, Adrien,Chan, Kai Cheong,Deverre, Jean Robert,et al.
, p. 343 - 347 (2007/10/02)
Four new bisbenzylisoquinoline alkaloids were obtained from Albertisia cf.A. papuana Becc. (Menispermaceae).These are (-)-2,2'-bisnorphaeanthine (5), (+)-pangkoramine (7), (+)-pangkorimine (9), and (+)-2'-norcocsuline (14).They are accompanied by the known (+)-daphnoline (2), which is the main alkaloid, and by seven known dimers with one, two, or three ether bridges
New alkaloids and related artifacts from Cyclea peltata
Kupchan,Liepa,Baxter,Hintz
, p. 1846 - 1852 (2007/10/04)
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