477886-49-0

Basic information

• Product Name: 9B-(4-CHLOROPHENYL)-1-(4-METHYLBENZOYL)-1,2,3,9B-TETRAHYDRO-5H-IMIDAZO[2,1-A]ISOINDOL-5-ONE
• Synonyms: 9B-(4-CHLOROPHENYL)-1-(4-METHYLBENZOYL)-1,2,3,9B-TETRAHYDRO-5H-IMIDAZO[2,1-A]ISOINDOL-5-ONE;9b-(4-chlorophenyl)-1-(4-methylbenzoyl)-1H,2H,3H,5H,9bH-imidazo[2,1-a]isoindol-5-one
• CAS NO: 477886-49-0
• Molecular Formula: C24H19ClN2O2
• Molecular Weight: 402.87
• Mol File: 477886-49-0.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 611.8±55.0 °C(Predicted)
• Appearance: /
• Density: 1.40±0.1 g/cm3(Predicted)
• PKA: -2.40±0.40(Predicted)
• CAS DataBase Reference: 9B-(4-CHLOROPHENYL)-1-(4-METHYLBENZOYL)-1,2,3,9B-TETRAHYDRO-5H-IMIDAZO[2,1-A]ISOINDOL-5-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 9B-(4-CHLOROPHENYL)-1-(4-METHYLBENZOYL)-1,2,3,9B-TETRAHYDRO-5H-IMIDAZO[2,1-A]ISOINDOL-5-ONE(477886-49-0)
• EPA Substance Registry System: 9B-(4-CHLOROPHENYL)-1-(4-METHYLBENZOYL)-1,2,3,9B-TETRAHYDRO-5H-IMIDAZO[2,1-A]ISOINDOL-5-ONE(477886-49-0)

Safety Data

• Hazardous Substances Data: 477886-49-0(Hazardous Substances Data)

Upstream product

• 85-56-3 2-(4-chlorobenzoyl)benzoic acid 
• 874-60-2 4-methyl-benzoyl chloride 
• 6038-49-9 9b-(p-chlorophenyl)-1,2,3,9b-tetrahydro-1H-imidazo[2,1-a]isoindol-5-one 

Relevant articles and documents

Discovery of the first M5-selective and CNS penetrant negative allosteric modulator (NAM) of a muscarinic acetylcholine receptor: (S)-9b-(4-chlorophenyl)-1-(3,4-difluorobenzoyl)-2,3-dihydro-1 H -imidazo[2,1- a ]isoindol-5(9b H)-one (ML375)

A functional high throughput screen and subsequent multidimensional, iterative parallel synthesis effort identified the first muscarinic acetylcholine receptor (mAChR) negative allosteric modulator (NAM) selective for the M5 subtype. ML375 is a