4785-56-2

Basic information

• Product Name: 2-FORMYL-5-METHOXY-BENZOIC ACID
• Synonyms: 2-FORMYL-5-METHOXY-BENZOIC ACID;2-carboxy-4-methoxybenzaldehyde
• CAS NO: 4785-56-2
• Molecular Formula: C₉H₈O₄
• Molecular Weight: 180.16
• Mol File: 4785-56-2.mol
• Article Data: 18

Chemical Properties

• Melting Point: 144 °C(Solv: water (7732-18-5))
• Boiling Point: 377.0±27.0 °C(Predicted)
• Appearance: /
• Density: 1.309±0.06 g/cm3(Predicted)
• PKA: 4.45±0.10(Predicted)
• CAS DataBase Reference: 2-FORMYL-5-METHOXY-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FORMYL-5-METHOXY-BENZOIC ACID(4785-56-2)
• EPA Substance Registry System: 2-FORMYL-5-METHOXY-BENZOIC ACID(4785-56-2)

Safety Data

• Hazardous Substances Data: 4785-56-2(Hazardous Substances Data)

Upstream product

• 41634-29-1 4-methoxybenzocyclobutene-1,2-dione 
• 3469-26-9 2,7-Dimethoxynaphthalene 
• 7732-18-5 water 
• 5486-55-5 2,6-dimethoxylnaphthalene 
• 1570134-65-4 N-(2-(4,5-dihydrooxazol-2-yl)phenyl)-3-methoxybenzamide 
• 586-38-9 3-Methoxybenzoic acid 
• 4741-63-3 6-methoxyphthalide 
• 1711-05-3 m-anisoyl chloride 
• 40125-47-1 3-Bromo-6-methoxy-3H-isobenzofuran-1-one 
• 68-12-2 N,N-dimethyl-formamide 
• 22921-68-2 2-bromo-5-methoxy-benzoic acid 

Downstream Products

• 103262-44-8 6-methoxy-3-nitromethyl-phthalide 
• 60889-22-7 7-methoxyphthalazin-1-(2H)-one 
• 871502-92-0 2-bis(5-methyl-2-furyl)methyl-5-methoxybenzoic acid 
• 102196-78-1 1-chloro-7-methoxyphthalazine 
• 85370-63-4 N,N-diethyl-2-formyl-5-methoxybenzamide 
• 1221486-40-3 2-(3-Aminophenethyl)-5-methoxybenzoic acid 
• 1221486-41-4 2-(3-chlorophenethyl)-5-methoxy-benzoic acid 
• 1374150-54-5 ethyl 2-formyl-5-methoxybenzoate 
• 1374149-87-7 2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-5-methoxy-N-methyl-benzamide 
• 1374150-55-6 2-[5-(2-amino-pyrimidin-5-yl)-1-tert-butyl-1H-benzoimidazol-2-yl]-5-methoxy-N-methyl-benzamide 

Relevant articles and documents

Cell-Trappable BODIPY-NBD Dyad for Imaging of Basal and Stress-Induced H2S in Live Biosystems

H2S is a gaseous signaling molecule that is involved in many physiological and pathological processes. In general, the level of intracellular H2S (1 μM) is much lower than that of GSH (～1–10 mM), leading to the remaining challenge o

Cu-Catalyzed C-H Alkenylation of Benzoic Acid and Acrylic Acid Derivatives with Vinyl Boronates

An efficient Cu-catalyzed C-H alkenylation with acyclic and cyclic vinyl boronates was realized for the first time under mild conditions. The scope of the vinyl borons and the compatibility with functional groups including heterocycles are superior than Pd-catalyzed C-H coupling with vinyl borons, providing a reliable access to multisubstituted alkenes and dienes. Subsequent hydrogenation of the product from the internal vinyl borons will lead to installation of secondary alkyls.

Sterically Shielded, Stabilized Nitrile Imine for Rapid Bioorthogonal Protein Labeling in Live Cells

In pursuit of fast bioorthogonal reactions, reactive moieties have been increasingly employed for selective labeling of biomolecules in living systems, posing a challenge in attaining reactivity without sacrificing selectivity. To address this challenge, here we report a bioinspired strategy in which molecular shape controls the selectivity of a transient, highly reactive nitrile imine dipole. By tuning the shape of structural pendants attached to the ortho position of the N-aryl ring of diaryltetrazoles-precursors of nitrile imines, we discovered a sterically shielded nitrile imine that favors the 1,3-dipolar cycloaddition over the competing nucleophilic addition. The photogenerated nitrile imine exhibits an extraordinarily long half-life of 102 s in aqueous medium, owing to its unique molecular shape that hinders the approach of a nucleophile as shown by DFT calculations. The utility of this sterically shielded nitrile imine in rapid (～1 min) bioorthogonal labeling of glucagon receptor in live mammalian cells was demonstrated.