85370-63-4Relevant articles and documents
Enantioselective synthesis of the dimeric pyranonaphthoquinone core of the cardinalins using a late-stage homocoupling strategy
Sperry, Jonathan,Gibson, Jennifer S.,Sejberg, Jimmy J. P.,Brimble, Margaret A.
supporting information; experimental part, p. 4261 - 4270 (2009/02/07)
The enantioselective synthesis of a dimeric pyranonaphthoquinone closely related to the cardinalins is described. Whilst attempts to effect a double Hauser-Kraus annulation of enone 5 were unsuccessful using both bis-phthalide 4 and bis-sulfone 21, a sing
Rational design of inhibitors of VirA-VirG two-component signal transduction
Maresh, Justin,Zhang, Jin,Tzeng, Yih-Ling,Goodman, Nora A.,Lynn, David G.
, p. 3281 - 3286 (2008/02/08)
VirA-VirG two-component system regulates the vir (virulence) operon in response to specific host factors (xenognosins) in the plant pathogen Agrobacterium tumefaciens. Using whole cell assays, stable inhibitors inspired by the labile natural benzoxazinone inhibitor HDMBOA are developed. It is found that aromatic aldehydes represent a minimal structural unit for activity. In particular, 3-hydroxy-4,6-dimethoxy-3H-isobenzofuran-1-one (HDI) was found to have the highest activity, making it the most potent developed inhibitor of virulence gene expression in Agrobacterium.
Directed Metalation of Tertiary Benzamides. Silicon Protection of Ortho Sites and Ortho Methyl Groups
Mills, R. J.,Snieckus, V.
, p. 1565 - 1568 (2007/10/02)
Metalation of 2-trimethylsilyl or 2-bis(trimethylsilyl)methyl benzamides occurs selectively at the 6-position, providing regiospecific routes to various trisubstituted benzenes.
