481-82-3 Usage
Description
1-[AMINO(PHENYL)METHYL]-2-NAPHTHOL HYDROCHLORIDE, also known as 2-Naphthalenol, 1-(aminophenylmethyl)-, is an organic compound that serves as a crucial intermediate in the synthesis of various organic and pharmaceutical compounds. It is characterized by its unique chemical structure, which allows it to participate in a wide range of chemical reactions and contribute to the development of new molecules with potential applications in different industries.
Uses
Used in Organic Synthesis:
1-[AMINO(PHENYL)METHYL]-2-NAPHTHOL HYDROCHLORIDE is used as an organic synthesis intermediate for the development of new organic compounds. Its unique chemical structure enables it to participate in various chemical reactions, leading to the formation of novel molecules with potential applications in different fields.
Used in Pharmaceutical Industry:
1-[AMINO(PHENYL)METHYL]-2-NAPHTHOL HYDROCHLORIDE is used as a pharmaceutical intermediate in the development of new drugs. Its versatile chemical properties make it an essential component in the synthesis of various pharmaceutical compounds, contributing to the advancement of medical treatments and therapies.
Used in Laboratory Research and Development:
1-[AMINO(PHENYL)METHYL]-2-NAPHTHOL HYDROCHLORIDE is used as a key compound in laboratory research and development processes. Its unique properties and reactivity make it an invaluable tool for scientists and researchers working on the discovery and development of new organic and pharmaceutical compounds.
Used in Chemical Production Process:
1-[AMINO(PHENYL)METHYL]-2-NAPHTHOL HYDROCHLORIDE is used in the chemical production process to synthesize various chemicals and materials. Its role as an intermediate allows for the efficient and cost-effective production of a wide range of products, contributing to the growth and innovation of the chemical industry.
Synthesis
Step 1General/Typical Procedure: General experimental procedures Method A: for compounds 3 (a-i). A mixture of aromatic/heteroaromatic aldehydes (2 mmol), 2-naphthol (1 mmol), and ammonium acetate (1.5 mmol) were taken in a beaker. The reaction mixture was hom ogenized with the help of glass rod and irradiated in microwave oven (360 W) by interval of 10 second. The progress of the reaction was monitored by TLC . After completion, the reaction mixture was cooled to room temperature and was poured over crushed ice. The obtained solid was filtered, dried, and recrystallized from ethanol. 1,3 oxazine derivative 3a, Yield: 98%, Time: 5 minutes. M.P: 147-149°C.Step 2General/Typical Procedure: General experim ental procedures for compounds 4 (a,d-f). Compounds 3(a, d-f) (1 mmol) were taken in 2 ml dil HCl in a beaker and followed by irradiation in a microwave (360 W) for about 5 min. KOH (0.2 mmol) was added and was then irradiated for the appropriate time until the completion of the reaction. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was cooled at room temperature and was poured on crushed ice. The obtained solid was filtered, dried, and recrystallized from ethanol. Aminobenzyl naphthol (Betti base) 4a, Yield: 95%, Time: 15 minutes. M.P: 173-175°C.
Check Digit Verification of cas no
The CAS Registry Mumber 481-82-3 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 1 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 481-82:
(5*4)+(4*8)+(3*1)+(2*8)+(1*2)=73
73 % 10 = 3
So 481-82-3 is a valid CAS Registry Number.
InChI:InChI=1/C17H15NO/c18-17(13-7-2-1-3-8-13)16-14-9-5-4-6-12(14)10-11-15(16)19/h1-11,17,19H,18H2
481-82-3Relevant articles and documents
Bianthryl-based organocatalysts for the asymmetric Henry reaction of fluoroketones
Otevrel, Jan,Svestka, David,Bobal, Pavel
supporting information, p. 5244 - 5248 (2019/06/07)
We have developed a catalytic system based on bianthrylbis(thiourea) for the asymmetric Henry reaction of fluoroketones and nitroalkanes that resulted from the screening of a library containing 31 chiral non-racemic organocatalysts. The corresponding adducts were isolated in up to 6 times shorter reaction time in comparison with the previously published organocatalysts. High levels of stereocontrol have been generally observed, with measured product enantiomeric excesses up to 97% and diastereomeric ratio 3:2 (anti/syn). The above-mentioned catalysts have been successfully applied to the total asymmetric synthesis of CF3-tethered (S)-halostachines, which has proved that this method constitutes an easy entry to similar enantiopure compounds.
Development of chiral heteroleptic magnesium amides; Asymmetric deprotonations mediated by six-membered metallocyclic amidomagnesium naphtholates
Carswell, Emma L.,Kerr, William J.,McArthur, Duncan,Pa?icky, Marek,Watson, Allan J.B.
, p. 7344 - 7349 (2016/01/25)
A series of enantioenriched six-membered metallocyclic amidomagnesium naphtholates were prepared and used to probe the structure-reactivity/selectivity relationships of heteroleptic magnesium base complexes within asymmetric deprotonation reactions. An ef
Synthesis, antimicrobial and cytotoxicity study of 1,3-disubstituted-1H- naphtho[1,2-e][1,3]oxazines
Verma, Vikas,Singh, Kuldeep,Kumar, Devinder,Klap?tke, Thomas M.,Stierstorfer, J?rg,Narasimhan, Balasubramanian,Qazi, Asif Khurshid,Hamid, Abid,Jaglan, Sundeep
, p. 195 - 202 (2013/01/15)
A series of new 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines (3 and 7) was synthesized in good yields and the structure was determined with the help of NMR, 2D-NMR, HRMS studies and X-ray crystallography. These compounds were tested in vitro for their
