481075-37-0

Basic information

• Product Name: 2-FLUORO-3-HYDROXYMETHYL-BENZOIC ACID
• Synonyms: 2-FLUORO-3-HYDROXYMETHYL-BENZOIC ACID
• CAS NO: 481075-37-0
• Molecular Formula: C8H7FO3
• Molecular Weight: 170.14
• Product Categories: pharmacetical
• Mol File: 481075-37-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 346.6 °C at 760 mmHg
• Flash Point: 163.4 °C
• Appearance: /
• Density: 1.417 g/cm³
• Storage Temp.: 2-8°C
• PKA: 3.27±0.10(Predicted)
• CAS DataBase Reference: 2-FLUORO-3-HYDROXYMETHYL-BENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-FLUORO-3-HYDROXYMETHYL-BENZOIC ACID(481075-37-0)
• EPA Substance Registry System: 2-FLUORO-3-HYDROXYMETHYL-BENZOIC ACID(481075-37-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 481075-37-0(Hazardous Substances Data)

Usage

Uses

2-?Fluoro-?3-?(hydroxymethyl)?benzoic Acid is a reagent used in the preparation of novel colchicine-derived immunosuppressants.

Upstream product

• 446-51-5 2-fluorobenzyl alcohol 
• 1260236-45-0 (2-fluoro-3-(hydroxymethyl)phenyl)(piperidine-1-yl)methanone 
• 1260236-43-8 methyl 2-fluoro-3-(piperidine-1-carbonyl)benzoate 
• 914301-44-3 2-fluoroisophthalic acid monomethyl ester 
• 723334-03-0 2-fluoro-isophthalic acid dimethyl ester 
• 1583-65-9 2-fluoro-isophthalic acid 
• 171670-20-5 methyl 3-(bromomethyl)-2-fluorobenzoate 
• 816449-66-8 methyl 2-fluoro-3-(hydroxymethyl)benzoate 
• 124-38-9 carbon dioxide 

Relevant articles and documents

METHOD FOR PREPARING TRICYCLIC DERIVATIVES

The present invention relates to a method for preparing a tricyclic derivative, and more particulary, to a method for preparing a tricyclic derivative inetermediate with high yield and purity, the method including: introducing a hydroxy group by esterifyi

Design, synthesis and identification of novel colchicine-derived immunosuppressant

Synthesis and biological evaluation of various colchicine analogues through the mixed-lymphocyte reaction (MLR), lymphoproliferation, and inhibitory effects on the inflammatory genes are described. In addition, a new series of immunosuppressive agents developed on the structural basis of colchicine, as well as their structure-activity relationships is reported. The most potent analogue 20a exhibited an excellent immunosuppressive activity on in vivo skin-allograft model, which is comparable to that of cyclosporin A.

Fluoro- or trifluoromethyl-substituted benzyl and phenethyl alcohols: Substrates for metal-mediated site-selective functionalization

It was possible to functionalize the three fluorobenzyl alcohols and the three 2-(fluorophenyl)ethanols by metalation and subsequent carboxylation, the prototype electrophilic trapping reaction. Triisopropylsilyl (TIPS) outperformed methoxymethyl (MOM) as an O-protective group making seven new fluorobenzoic acids accessible in 63% average yield. Moreover, the TIPS group tolerates weakly basic and acidic media and, therefore, may facilitate further structural elaboration. The unprotected alcohols reacted more sluggishly and were unable to provide two of the targeted products (acids 1 and 2). The yield averaged only 46% in the five other cases (acids 3-7). The direct metalation of fluorinated benzyl and phenethyl alcohols remains nevertheless an attractive option because of its operational simplicity. All three (trifluoromethyl)benzyl alcohols and two of the three (trifluoromethyl)phenethyl alcohol isomers were successfully submitted to the metalation/functionalization sequence. These five starting materials gave rise to a total of nine new benzoic acids or lactones (compounds 8-14 and 17-18). Despite the poor yields (31% on average), the organometallic methods employed are, in general, extremely selective, economical and easy to perform. Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002.