482-22-4 Usage
Description
Cryptopleurine is an organic heteropentacyclic compound, specifically a phenanthroindolizidine alkaloid, characterized by its unique structure with (14aR)-11,12,13,14,14a,15-hexahydro-9H-dibenzo[f,h]pyrido[1,2-b]isoquinoline substituted at positions 2, 3, and 6 by methoxy groups. It possesses significant anti-cancer therapeutic potentials, making it a valuable compound in the field of pharmaceutical research and development.
Uses
Used in Pharmaceutical Industry:
Cryptopleurine is used as an anti-cancer agent for its therapeutic potentials against various types of cancer. It has shown promise in targeting and inhibiting cancer cell growth, making it a valuable compound in the development of novel cancer treatments.
Used in Cancer Research:
In the field of cancer research, cryptopleurine is utilized as a key compound for studying the mechanisms of cancer cell growth and proliferation. Its unique structure and properties allow researchers to investigate new approaches to combat cancer and develop more effective therapies.
Used in Drug Development:
Cryptopleurine is also used in the development of new drugs and drug delivery systems, as its anti-cancer properties can be harnessed to create more targeted and effective treatments. By incorporating cryptopleurine into drug formulations, researchers aim to improve the efficacy of cancer therapies and reduce side effects associated with traditional chemotherapy.
Check Digit Verification of cas no
The CAS Registry Mumber 482-22-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 4,8 and 2 respectively; the second part has 2 digits, 2 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 482-22:
(5*4)+(4*8)+(3*2)+(2*2)+(1*2)=64
64 % 10 = 4
So 482-22-4 is a valid CAS Registry Number.
InChI:InChI=1/C24H27NO3/c1-26-16-7-8-17-19(11-16)21-13-24(28-3)23(27-2)12-20(21)18-10-15-6-4-5-9-25(15)14-22(17)18/h7-8,11-13,15H,4-6,9-10,14H2,1-3H3/t15-/m1/s1
482-22-4Relevant articles and documents
Total Synthesis of Cryptopleurine and Its Analogues
Takasu, Kiyosei,Tateishi, Kaito,Yamakawa, Takuro,Yamaoka, Yousuke
, (2022/03/08)
Total synthesis of phenanthroquinolizidine alkaloid cryptopleurine was achieved in 8 steps from commercially available 2-pyridinecarboxaldehyde and the epoxide derived from methyleugenol. The key intermediate vinyl triflate enables the divergent synthesis of cryptopleurine derivatives by late-stage installation of various substituents on the C-ring.
Synthesis and biological evaluation of (-)-6-O-desmethylcryptopleurine and analogs
Liéby-Muller, Frédéric,Marion, Frédéric,Schmitt, Philippe,Annereau, Jean-Philippe,Kruczynski, Anna,Guilbaud, Nicolas,Bailly, Christian
, p. 184 - 187 (2015/04/13)
(-)-Cryptopleurine 1 is one of the most potent anti-proliferative member of the phenanthroquinolizidine class of alkaloids. We report here the synthesis of (-)-6-O-desmethylcryptopleurine (-)-2 and (-)-6-O-desmethyl-(15R)-hydroxycryptopleurine (-)-4 in th
Collective asymmetric synthesis of (-)-Antofine, (-)-cryptopleurine, (-)-tylophorine, and (-)-tylocrebrine with tert- butanesulfinamide as a chiral auxiliary
Zheng, Yanlong,Liu, Yuxiu,Wang, Qingmin
supporting information, p. 3348 - 3357 (2014/05/06)
A collective asymmetric synthesis of phenanthroindolizidine and phenanthroquinolizidine alkaloids (-)-antofine, (-)-cryptopleurine, (-)-tylophorine, and (-)-tylocrebrine was achieved by means of a reaction sequence involving efficient generation of chiral homoallylic amine intermediates by asymmetric allylation of the corresponding tert-butanesulfinyl imine. From these intermediates, the pyrrolidine and piperidine rings were constructed by means of an intramolecular SN2 substitution reaction and a ring-closing metathesis reaction, respectively. The unusual C5-methoxy-substituted phenanthrene moiety of (-)-tylocrebrine was generated by means of an InCl3-catalyzed cycloisomerization reaction of an o-propargylbiaryl compound.
