4850-50-4

Basic information

• Product Name: 1-phenylbutane-1,4-diol
• Synonyms: 1,4-butanediol, 1-phenyl-; 1-Phenylbutane-1,4-diol
• CAS NO: 4850-50-4
• Molecular Formula: C₁₀H₁₄O₂
• Molecular Weight: 166.217
• Mol File: 4850-50-4.mol
• Article Data: 66

Chemical Properties

• Boiling Point: 316.1°C at 760 mmHg
• Flash Point: 153.9°C
• Density: 1.1g/cm³
• Vapor Pressure: 0.000176mmHg at 25°C
• Refractive Index: 1.55
• CAS DataBase Reference: 1-phenylbutane-1,4-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenylbutane-1,4-diol(4850-50-4)
• EPA Substance Registry System: 1-phenylbutane-1,4-diol(4850-50-4)

Safety Data

• Hazardous Substances Data: 4850-50-4(Hazardous Substances Data)

Usage

General Description

1-Phenylbutane-1,4-diol is a chemical compound with the molecular formula C10H14O2. It is also known as 1,4-Dihydroxyphenylbutane and is a type of diol, containing two hydroxyl groups. 1-Phenylbutane-1,4-diol is used in the production of various industrial and consumer products such as cosmetics, pharmaceuticals, and lubricants. It is often used as a precursor in the synthesis of polymers and other compounds. 1-Phenylbutane-1,4-diol is a colorless, crystalline solid with a mild, sweet odor. It is considered to be relatively safe for use in these applications, however, as with all chemicals, proper handling and storage procedures should be followed to minimize risks to human health and the environment.

Upstream product

• 80735-94-0 1-Phenyl-3-buten-1-ol 
• 6270-17-3 ethyl 3-benzoylpropanoate 
• 111138-03-5 (R)-4-phenylbutyrolactone 
• 25333-24-8 3-benzoylpropionic acid methyl ester 
• 1008-76-0 4,5-dihydro-5-phenyl-2(3H)-furanone 
• 139527-16-5 (S)-4-hydroxy-4-phenylbutyl acetate 
• 136113-08-1 (R)-2'-[2-(2-Methoxyethoxy)ethoxy]-1,1'-binaphthalen-2-yl 3-benzoylpropionate 
• 6249-80-5 1-phenylbut-3-en-1-one 
• 99512-38-6 (R)-methyl 4-hydroxy-4-phenylbutanoate 

Downstream Products

• 219745-25-2 4-chloro-4-phenyl-1-butanol 
• 139527-16-5 (S)-4-hydroxy-4-phenylbutyl acetate 
• 111138-02-4 (-)-(S)-5-phenyl-4,5-dihydrofuran-2(3H)-one 
• 111138-03-5 (R)-4-phenylbutyrolactone 
• 4850-50-4 (R)-(+)-1-Phenylbutane-1,4-diol 
• 4850-50-4 (S)-(-)-1-Phenylbutane-1,4-diol 
• 1376191-20-6 C₂₇H₃₅N 
• 1006-64-0 (S)-2-phenylpyrrolidine 
• 1376191-46-6 (2S)-N-allyl-2-phenylpyrrolidine 
• 164850-19-5 (S)-2-phenyltetrahydrothiophene 
• 1438891-80-5 (2S)-phenyltetrahydrothiophene-1,1-dioxide 
• 127921-80-6 (E)-4-oxo-4-phenylbut-2-enal 
• 16133-83-8 (S)-2-phenyltetrahydrofuran 
• 71052-93-2 1-phenyl-1,4-dibromobutane 

Relevant articles and documents

Hydroboration Reaction and Mechanism of Carboxylic Acids using NaNH2(BH3)2, a Hydroboration Reagent with Reducing Capability between NaBH4and LiAlH4

Hydroboration reactions of carboxylic acids using sodium aminodiboranate (NaNH2[BH3]2, NaADBH) to form primary alcohols were systematically investigated, and the reduction mechanism was elucidated experimentally and computationally. The transfer of hydride ions from B atoms to C atoms, the key step in the mechanism, was theoretically illustrated and supported by experimental results. The intermediates of NH2B2H5, PhCH= CHCOOBH2NH2BH3-, PhCH= CHCH2OBO, and the byproducts of BH4-, NH2BH2, and NH2BH3- were identified and characterized by 11B and 1H NMR. The reducing capacity of NaADBH was found between that of NaBH4 and LiAlH4. We have thus found that NaADBH is a promising reducing agent for hydroboration because of its stability and easy handling. These reactions exhibit excellent yields and good selectivity, therefore providing alternative synthetic approaches for the conversion of carboxylic acids to primary alcohols with a wide range of functional group tolerance.

Aryl Boronic Acid Catalysed Dehydrative Substitution of Benzylic Alcohols for C?O Bond Formation

A combination of pentafluorophenylboronic acid and oxalic acid catalyses the dehydrative substitution of benzylic alcohols with a second alcohol to form new C?O bonds. This method has been applied to the intermolecular substitution of benzylic alcohols to form symmetrical ethers, intramolecular cyclisations of diols to form aryl-substituted tetrahydrofuran and tetrahydropyran derivatives, and intermolecular crossed-etherification reactions between two different alcohols. Mechanistic control experiments have identified a potential catalytic intermediate formed between the aryl boronic acid and oxalic acid.

Method for synthesizing alkyne through catalytic asymmetric cross coupling (by machine translation)

The invention belongs to the field of, asymmetric synthesis, and discloses a method for catalyzing asymmetric cross- coupling to synthesize: an alkyne, and the L method comprises, the following steps, of A: preparing B a cuprous, salt and C a: ligand; preparing a catalyst; adding a base; reacting the compound with the compound with the compound; and reacting the compound with the compound. Of these, one of them, X is selected from the group consisting of, R halogens. 1 Optionally substituted heteroarylsulfonylcyanamide groups selected from the, group consisting, of optionally substituted, phenyl groups In-flight vehicle, R6 Trialkyl silyl groups or alkyl radicals, R2 Cycloalkyl radicals optionally substituted with an, optionally substituted alkyl, (CH radical2 )n R4 Multi,layer chain, n＝0-10,R saw blade4 A group selected, from, the group consisting of phenyl, alkenyl, aralkynyls, noonyloxy,and, noonylsulfonylsulfonylsulfonylsulfonylsulfonylsulfonylsulfonylsulfonylsulfonylsulphonylsulphonylsulphonylsulphonylsulphonylsulphonylsulphonylsulphonylsulphonylsulphonylphenyl disiloxy-radicals. R3 A ligand, selected from hydrogen or any of the functional groups, is selected from the group consisting of, hydrogen and any L other functional group. The method, R disclosed by the, A invention has the, advantages of good catalytic, R ’ effect, wide application range. and high catalytic efficiency, and the, method disclosed by the, invention has the. advantages of good catalytic effect, wide application range and high catalytic efficiency. (by machine translation)