485799-04-0

Basic information

• Product Name: 6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester
• Synonyms: 4-[5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)-2-PYRIDINYL]MORPHOLINE;4-[5-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDIN-2-YL]-MORPHOLINE;6-(MORPHOLIN-4-YL)PYRIDINE-3-BORONIC ACID PINACOL ESTER;6-MORPHOLINOPYRIDINE-3-BORONIC ACID, PINACOL ESTER;2-(4-MORPHOLINO)PYRIDINE-5-BORONIC ACID PINACOL ESTER;2-MORPHOLINOPYRIDINE-5-BORONIC ACID, PINACOL ESTER;2-(MORPHOLIN-4-YL)PYRIDINE-5-BORONIC ACID PINACOL ESTER;2-MORPHOLINE-4-YL-PYRIDINE-5-BORONIC ACID PINACOL ESTER
• CAS NO: 485799-04-0
• Molecular Formula: C₁₅H₂₃BN₂O₃
• Molecular Weight: 290.17
• Product Categories: Amino;Organoborons;Pyridine;Boric Acid| Boric Acid Ester| Potassium Trifluoroborate
• Mol File: 485799-04-0.mol
• Article Data: 4

Chemical Properties

• Melting Point: 135-139 °C(lit.)
• Boiling Point: 440.929 °C at 760 mmHg
• Flash Point: 220.466 °C
• Appearance: /
• Density: 1.13 g/cm³
• Vapor Pressure: 5.67E-08mmHg at 25°C
• Refractive Index: 1.53
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 5.58±0.10(Predicted)
• CAS DataBase Reference: 6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester(485799-04-0)
• EPA Substance Registry System: 6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester(485799-04-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 22-24/25-45-43A-36/37/39-26
• RIDADR: 2811
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 485799-04-0(Hazardous Substances Data)

Usage

General Description

6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester is a chemical compound commonly used in organic synthesis and medicinal chemistry. It is an important building block for the preparation of various pharmaceuticals and agrochemicals due to its boronic acid functionality, which allows for the formation of carbon-carbon bonds through Suzuki-Miyaura cross-coupling reactions. 6-(Morpholin-4-yl)pyridine-3-boronic acid pinacol ester is also known for its potential as a ligand in metal-catalyzed reactions and as a key intermediate in the synthesis of biologically active molecules. Its pinacol ester derivative provides stability and protection against potential side reactions, making it a valuable tool in the field of chemical synthesis.

InChI:InChI=1/C15H23BN2O3/c1-14(2)15(3,4)21-16(20-14)12-5-6-13(17-11-12)18-7-9-19-10-8-18/h5-6,11H,7-10H2,1-4H3

Upstream product

• 73183-34-3 bis(pinacol)diborane 
• 200064-11-5 5-bromo-2-(4-morpholinyl)pyridine 
• 53939-30-3 5-bromo-2-chloropyridine 

Downstream Products

• 1083428-82-3 6-(4-ethoxy-3-methoxy-phenyl)-2-methyl-3-(6-morpholin-4-yl-pyridin-3-yl)-imidazo[1,2-b]pyridazine 
• 1083428-86-7 6-(4'-methoxy-biphenyl-4-yl)-2-methyl-3-(6-morpholin-4-yl-pyridin-3-yl)-imidazo[1,2-b]pyridazine 
• 1040376-61-1 4-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-6-(6-morpholin-4-yl-pyridin-3-yl)-pyridazin-3-ylamine 
• 1279028-31-7 tert-butyl [2-(methyl{3-[6-(morpholin-4-yl)pyridin-3-yl]benzyl}amino)-2-oxoethyl]carbamate 
• 259260-15-6 1-(6-morpholinopyridin-3-yl)-3-phenylpropanone 

Relevant articles and documents

INDOLE AHR INHIBITORS AND USES THEREOF

The present invention provides compounds useful as inhibitors of AHR, compositions thereof, and methods of using the same.

PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS

Provided are compounds according to Formula (I), or stereoisomer, prodrug, polymorph, or pharmaceutically acceptable salt forms thereof, wherein X, Y, R1, R6 , R7, and R8 are as defined, which compounds are effective inhibitors of PI3-kinase and/or other medically and clinically relevant kinases. Also provided are pharmaceutical compositions and methods of using the compounds and compositions as PB -kinase and kinase inhibitors. More particularly, the compounds of the invention provide treatments and therapeutics for human diseases regulated by, or associated with, the activity of, PI3-kinases and/or protein kinases, or mutant or variant forms thereof.