486422-58-6 Usage
General Description
4-(1-Piperidinylsulfonyl)phenylboronic acid is a chemical compound used as a building block in organic synthesis. It belongs to the class of boronic acids, which are important reagents in Suzuki-Miyaura cross-coupling reactions to form carbon-carbon bonds. 4-(1-PIPERIDINYLSULFONYL)PHENYLBORONIC ACID has a reactive boronic acid group attached to a phenyl ring, as well as a piperidine sulfonamide group, which makes it useful in medicinal chemistry for the development of potential pharmaceutical drugs. The compound is also employed in the field of materials science for the production of functional organic materials. Overall, 4-(1-Piperidinylsulfonyl)phenylboronic acid is a versatile compound with diverse applications in chemical synthesis and material science.
Check Digit Verification of cas no
The CAS Registry Mumber 486422-58-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,8,6,4,2 and 2 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 486422-58:
(8*4)+(7*8)+(6*6)+(5*4)+(4*2)+(3*2)+(2*5)+(1*8)=176
176 % 10 = 6
So 486422-58-6 is a valid CAS Registry Number.
InChI:InChI=1/C11H16BNO4S/c14-12(15)10-4-6-11(7-5-10)18(16,17)13-8-2-1-3-9-13/h4-7,14-15H,1-3,8-9H2
486422-58-6Relevant articles and documents
Discovery of novel potent and highly selective glycogen synthase kinase-3β (GSK3β) inhibitors for Alzheimers Disease: Design, synthesis, and characterization of pyrazines
Berg, Stefan,Bergh, Margareta,Hellberg, Sven,Hoegdin, Katharina,Lo-Alfredsson, Yvonne,Soederman, Peter,Von Berg, Stefan,Weigelt, Tatjana,Ormoe, Mats,Xue, Yafeng,Tucker, Julie,Neelissen, Jan,Jerning, Eva,Nilsson, Yvonne,Bhat, Ratan
supporting information, p. 9107 - 9119,13 (2020/10/15)
Glycogen synthase kinase-3β, also called tau phosphorylating kinase, is a proline-directed serine/threonine kinase which was originally identified due to its role in glycogen metabolism. Active forms of GSK3β localize to pretangle pathology including dystrophic neuritis and neurofibrillary tangles in Alzheimers disease (AD) brain. By using a high throughput screening (HTS) approach to search for new chemical series and cocrystallization of key analogues to guide the optimization and synthesis of our pyrazine series, we have developed highly potent and selective inhibitors showing cellular efficacy and bloo-brain barrier penetrance. The inhibitors are suitable for in vivo efficacy testing and may serve as a new treatment strategy for Alzheimers disease.
