495-86-3

Basic information

• Product Name: (2E)-3-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)prop-2-enamide
• Synonyms: (2E)-3-(1,3-Benzodioxol-5-yl)-N-isobutylacrylamide; 2-Propenamide, 3- (1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-, (E)-; 2-propenamide, 3-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)-, (2E)-; 60045-88-7; Cinnamamide, N-isobutyl-3,4-(methylenedioxy)-, (E)-; N1-isobutyl-3-(1,3-benzodioxol-5-yl)acrylamide
• CAS NO: 495-86-3
• Molecular Formula: C₁₄H₁₇NO₃
• Molecular Weight: 247.2897
• Mol File: 495-86-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 441.4°C at 760 mmHg
• Flash Point: 220.8°C
• Density: 1.155g/cm³
• Vapor Pressure: 5.45E-08mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: (2E)-3-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)prop-2-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)prop-2-enamide(495-86-3)
• EPA Substance Registry System: (2E)-3-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)prop-2-enamide(495-86-3)

Safety Data

• Hazardous Substances Data: 495-86-3(Hazardous Substances Data)

Usage

Description

(2E)-3-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)prop-2-enamide is an amide derivative with a molecular formula of C15H19NO3. It features a benzodioxole ring and a propenamide functional group, and it is an enantiomer with a trans configuration at the C=C bond. This chemical compound may have potential applications in medicinal chemistry, particularly in the development of pharmaceuticals and drug discovery.

Uses

Used in Pharmaceutical Industry:
(2E)-3-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)prop-2-enamide is used as a chemical intermediate for the synthesis of various pharmaceuticals. Its unique structure, including the benzodioxole ring and propenamide functional group, may contribute to the development of new drugs with specific therapeutic properties.
Used in Drug Discovery:
(2E)-3-(1,3-benzodioxol-5-yl)-N-(2-methylpropyl)prop-2-enamide is used as a potential lead compound in drug discovery. Its structural features may allow for the design and optimization of new therapeutic agents targeting specific biological pathways or receptors.
Further research and investigation are needed to fully understand the properties and potential uses of this compound in various applications.

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 120-57-0 piperonal 
• 78-81-9 isobutylamine 
• 96249-87-5 (E)-3-(1,3-benzodioxol-5-yl)acryloyl chloride 
• 2373-80-0 3,4-methylenedioxy-trans-cinnamic acid 
• 73818-55-0 Bestmann ylide 
• 74058-80-3 3-(3,4-methylenedioxycinnamoyl)-1,3-thiazolidine-2-thione 
• 96249-87-5 3-benzo[1,3]dioxol-5-yl-acryloyl chloride 

Downstream Products

• 120-57-0 piperonal 
• 94-53-1 Piperonylic acid 

Relevant articles and documents

Mild, Metal-Free and Protection-Free Transamidation of N-Acyl-2-piperidones to Amino Acids, Amino Alcohols and Aliphatic Amines and Esterification of N-Acyl-2-piperidones

Amides are indispensable building blocks of biological systems, pharmaceuticals, and materials. We report a highly selective method for the synthesis of amides via transamidation process. Transamidation of N-acyl-2-piperidones with a broad range of amines is demonstrated under exceedingly mild and metal-free reaction condition that relies on the amide bond twist to weaken the amidic resonance. Transamidation proceeds under the neat condition at room temperature, in short reaction times (30–90 min) with good yields. Considerable variation is tolerated with both amine and imide substrates. Of note, amines bearing carboxylic acids (glycine and serine) and hydroxyl groups (dopamine, tyramine, etc.) are well tolerated which are otherwise problematic under the metal-catalyzed protocol. Our current method is applicable for transamidation of both alkyl and aryl-N-acyl-2-piperidones. The practical value of the method is highlighted by the synthesis of four natural product amide alkaloids in high yields under mild reaction conditions. In the absence of nucleophilic amines, N-acyl-2-piperidones undergoes esterification with EtOH at elevated temperature. Single crystal X-ray analysis of an N-acyl-2-piperidone shows amide bond twist, τ = –20.39° and pyramidalization, χN = –11.73°. This weakens the amidic conjugation and might be the factor controlling the reactivity and selectivity of these imides. We envision that the N-acyl-2-piperidone scaffold would be useful in the synthesis of pharmaceuticals and materials.

Synthesis of Analogs of Trans-Fagaramide and Their Cytotoxic Activity

A series of 30 compounds were synthetized inspired by active trans-fagaramide structure skeleton. On this synthetic platform, 18 compounds were achieved via Knoevenagel condensation using maleic acid and piperonal, followed by peptide coupling with various amines, giving an average yield of 54%. Subsequently, nine compounds were obtained by palladium-mediated Heck coupling with an average yield of 79%. In addition, cytotoxic activity was evaluated against cardiomyoblast H9c2, breast adenocarcinoma MCF7, hepatocellular carcinoma HepG2, and glioblastoma U-87 cells. The results revealed two aryl halogen-substituted compounds moderately active against H9c2 and MCF7 with IC50 values > 50 μM. One functionalized coumarin showed inhibitory activity against H9c2 (IC50 > 50 μM). In contrast, p-aminophenyl-β-monosubstituted trans-fagaramide was found to inhibit MCF7 (IC50 > 50 μM) without showing toxicity against H9c2 cells.

Three-component synthesis of (E)-α,β-unsaturated amides of the piperine family

Selective formation of (E)-α,β-unsaturated amides by intermolecular three-component reaction between aldehydes, amines (1° or 2°) and ketenylidenetriphenylphosphorane (Ph3P=C=C=O) is described. Natural amides such as fagaramide and piperines could be prepared from immediately available educts. The method is shown to be extendable to the preparation of thioesters from thiols and aldehydes.