4959-17-5

Basic information

• Product Name: 7-AMINOCLONAZEPAM
• Synonyms: 7-AMINOCLONAZEPAM;7-Amino-5-(2-chlorophenyl)-1,3-dihydro-2H-1,4-Benzodiazepin-2-one;7-Amino-5-(o-chlorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one;Aminoclonazepam;Chloraminazepam;Ro 5-461;2H-1,4-Benzodiazepin-2-one, 7-amino-5-(2-chlorophenyl)-1,3-dihydro-;7-AMINOCLONAZEPAM,1.0MG/MLINACETONITRILE
• CAS NO: 4959-17-5
• Molecular Formula: C₁₅H₁₂ClN₃O
• Molecular Weight: 285.73
• EINECS: 200-835-2
• Product Categories: Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals;Aromatics;Heterocycles
• Mol File: 4959-17-5.mol
• Article Data: 6

Chemical Properties

• Melting Point: 226-228°C
• Boiling Point: 523.5 °C at 760 mmHg
• Flash Point: 2℃
• Appearance: /
• Density: 1.41 g/cm³
• Vapor Pressure: 4.69E-11mmHg at 25°C
• Refractive Index: 1.696
• Storage Temp.: Controlled Substance, -20?C Freezer
• PKA: 12.15±0.70(Predicted)
• CAS DataBase Reference: 7-AMINOCLONAZEPAM(CAS DataBase Reference)
• NIST Chemistry Reference: 7-AMINOCLONAZEPAM(4959-17-5)
• EPA Substance Registry System: 7-AMINOCLONAZEPAM(4959-17-5)

Safety Data

• Hazard Codes: F,Xn
• Statements: 11-20/21/22-36
• Safety Statements: 16-36/37-26
• RIDADR: UN 1648 3 / PGII
• WGK Germany: 2
• Hazardous Substances Data: 4959-17-5(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Uses

The major metabolite of Clonazepam (C587080).

InChI:InChI=1/C15H12ClN3O/c16-12-4-2-1-3-10(12)15-11-7-9(17)5-6-13(11)19-14(20)8-18-15/h1-7H,8,17H2,(H,19,20)

Upstream product

• 364046-84-4 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one 
• 3900-89-8 2-Chlorobenzeneboronic acid 
• 17420-30-3 5-nitroanthranilonitrile 
• 52130-87-7 2-bromo-2'-(2-chlorobenzoyl)-4'-nitroacetanilide 
• 2011-66-7 2'-chloro-5-nitro-2-aminobenzophenone 
• 10073-89-9 2-methyl-6-nitro-4H-benzo[d][1,3]oxazin-4-one 
• 616-79-5 2-amino-5-nitro-benzoic acid 

Relevant articles and documents

Method for synthesizing 7-amino clonazepam compound

The invention discloses a method for synthesizing a 7-amino clonazepam compound, and belongs to the technical field of organic synthesis. The preparation method comprises the steps that 2-cyano-4-nitroaniline serves as an initial raw material, and a target compound is obtained through oxidative coupling, amidation, affinity substitution reaction, intramolecular Wittig reaction, reduction reaction and other processes. According to the invention, a brand new synthetic route is provided for 7-amino nitrazepam, the method has the advantages of short synthetic steps, safe operation and simple post-treatment, only conventional acid-base and solvent are used in the whole reaction process, the cost is low, and the yield is increased by more than 20%.

Substrate selectivity of human aldehyde oxidase 1 in reduction of nitroaromatic drugs

Human aldehyde oxidase 1 (AOX1) catalyzes the oxidation of various drugs and endogenous compounds. Recently, we found that AOX1 catalyzed the reduction of drugs such as nitrazepam and dantrolene. In this study, we aimed to clarify the substrate selectivit

REDUCTION OF NITRO DERIVATIVES OF 1,2-DIHYDRO-3H-1,4-BENZDIAZEPIN-2-ONES BY IMMOBILIZED CELLS OF E. coli

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