52130-87-7

Basic information

• Product Name: 2-bromo-N-[2-(2-chlorobenzoyl)-4-nitrophenyl]acetamide
• Synonyms: 2-bromo-N-[2-(2-chlorobenzoyl)-4-nitrophenyl]acetamide;2-Brom-N-(2-(2-chlorbenzoyl)-4-nitrophenyl)acetamid;Einecs 257-681-4;ClonazepaM USP Related CoMpound C;2-Bromo-N-[2-(2-chlorobenzoyl)-4-nitrophenyl]acetamide (Clonazepam Impurity);Clonazepam Impurity C(USP)
• CAS NO: 52130-87-7
• Molecular Formula: C15H10BrClN2O4
• Molecular Weight: 397.6079
• EINECS: 257-681-4
• Product Categories: Aromatics;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals;MTS & Sulfhydryl Active Reagents
• Mol File: 52130-87-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 616.7°C at 760 mmHg
• Flash Point: 326.8°C
• Appearance: /
• Density: 1.673g/cm³
• Vapor Pressure: 3.84E-15mmHg at 25°C
• Refractive Index: 1.677
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 10.59±0.70(Predicted)
• CAS DataBase Reference: 2-bromo-N-[2-(2-chlorobenzoyl)-4-nitrophenyl]acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-N-[2-(2-chlorobenzoyl)-4-nitrophenyl]acetamide(52130-87-7)
• EPA Substance Registry System: 2-bromo-N-[2-(2-chlorobenzoyl)-4-nitrophenyl]acetamide(52130-87-7)

Safety Data

• Hazardous Substances Data: 52130-87-7(Hazardous Substances Data)

Usage

Chemical Properties

Beige Solid

Uses

An impurity from the synthesis of clonazepam (C587080)

InChI:InChI=1/C15H10BrClN2O4/c16-8-14(20)18-13-6-5-9(19(22)23)7-11(13)15(21)10-3-1-2-4-12(10)17/h1-7H,8H2,(H,18,20)

Upstream product

• 3900-89-8 2-Chlorobenzeneboronic acid 
• 17420-30-3 5-nitroanthranilonitrile 
• 10073-89-9 2-methyl-6-nitro-4H-benzo[d][1,3]oxazin-4-one 
• 616-79-5 2-amino-5-nitro-benzoic acid 
• 2011-66-7 2'-chloro-5-nitro-2-aminobenzophenone 
• 598-21-0 2-Bromoacetyl bromide 
• 609-65-4 o-chlorobenzoyl chloride 
• 100-01-6 4-nitro-aniline 

Downstream Products

• 364046-84-4 5-(2-chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one 
• 4959-17-5 7-Aminoclonazepam 

Relevant articles and documents

Method for synthesizing clonazepam compound

The invention discloses a method for synthesizing a clonazepam compound, and belongs to the technical field of organic chemical synthesis, and the preparation method comprises the following steps: by taking 2-amino-4-nitrophenyl potassium trifluoroborate as an initial raw material, carrying out oxidative coupling, amidation, affinity substitution reaction, intramolecular condensation reaction and the like to obtain a target compound; the method disclosed by the invention is short in synthesis step, safe to operate and simple and convenient in post-treatment, and the product can be obtained by directly filtering and leaching without other purification; only conventional acid, alkali and solvents are used in the whole reaction process, the cost is low, and the yield is increased by 30% or above.

Method for synthesizing 7-amino clonazepam compound

The invention discloses a method for synthesizing a 7-amino clonazepam compound, and belongs to the technical field of organic synthesis. The preparation method comprises the steps that 2-cyano-4-nitroaniline serves as an initial raw material, and a target compound is obtained through oxidative coupling, amidation, affinity substitution reaction, intramolecular Wittig reaction, reduction reaction and other processes. According to the invention, a brand new synthetic route is provided for 7-amino nitrazepam, the method has the advantages of short synthetic steps, safe operation and simple post-treatment, only conventional acid-base and solvent are used in the whole reaction process, the cost is low, and the yield is increased by more than 20%.