4967-77-5

Basic information

• Product Name: Methyl 1,2,3-Triazole-4-carboxylate
• Synonyms: Methyl 1,2,3-Triazole-4-carboxylate;Methyl 1H-1,2,3-triazole-4-carboxylate;1H-1,2,3-Triazole-4-carboxylic acid, Methyl ester;1H-1,2,3-Triazole-5-CarboxylicacidMethylester;methyl 2H-1,2,3-triazole-4-carboxylate;methyl 2H-triazole-4-carboxylate
• CAS NO: 4967-77-5
• Molecular Formula: C₄H₅N₃O₂
• Molecular Weight: 127.1014
• Mol File: 4967-77-5.mol
• Article Data: 12

Chemical Properties

• Melting Point: 13.5-13.8 °C
• Boiling Point: 279.3°C at 760 mmHg
• Flash Point: 122.7°C
• Appearance: /
• Density: 1.38g/cm³
• Vapor Pressure: 0.00405mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: 2-8°C
• PKA: 6.84±0.70(Predicted)
• CAS DataBase Reference: Methyl 1,2,3-Triazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 1,2,3-Triazole-4-carboxylate(4967-77-5)
• EPA Substance Registry System: Methyl 1,2,3-Triazole-4-carboxylate(4967-77-5)

Safety Data

• Hazardous Substances Data: 4967-77-5(Hazardous Substances Data)

Usage

General Description

Methyl 1,2,3-triazole-4-carboxylate is a chemical compound with the molecular formula C5H5N3O2. It is a member of the triazole family of compounds, which are known for their diverse range of biological activities. Methyl 1,2,3-triazole-4-carboxylate has been studied for its potential pharmaceutical applications, particularly as a building block in the synthesis of new drug candidates. It is also used as an intermediate in organic synthesis and has been investigated for its antimicrobial and anticancer properties. As a versatile compound, methyl 1,2,3-triazole-4-carboxylate has garnered attention for its potential applications in the fields of medicine, agriculture, and materials science.

InChI:InChI=1/C4H5N3O2/c1-9-4(8)3-2-5-7-6-3/h2H,1H3,(H,5,6,7)

Upstream product

• 922-67-8 propynoic acid methyl ester 
• 90087-77-7 methyl 3-pyrrolidinoacrylate 
• 63806-67-7 5-methylthiophene-2-carbonyl azide 
• 477283-86-6 thieno[3,2-b]thiophene-2-carbonyl azide 
• 20762-98-5 2-furoyl azide 
• 2046-39-1 2-thiophenecarbonyl azide 
• 4648-54-8 trimethylsilylazide 
• 76003-76-4 1-benzyl-1H-[1,2,3]triazole-4-carboxylic acid methyl ester 

Downstream Products

• 497855-41-1 methyl 2-propyl-1H-1,2,3-triazol-4-carboxylate 
• 497855-39-7 methyl 2-propyl-1H-1,2,3-triazol-4-carboxylate 
• 497855-40-0 methyl 1-propyl-1H-1,2,3-triazol-5-carboxylate 
• 16681-70-2 1H-1,2,3-triazole-4-carboxylic acid 
• 215872-74-5 3-ethyl-3H-[1,2,3]triazole-4-carboxylic acid methyl ester 
• 215868-68-1 methyl 2-ethyl-1,2,3-triazole-4-carboxylate 
• 105020-38-0 methyl 1-methyl-1H-1,2,3-triazole-5-carboxylate 
• 105020-39-1 2-Methyl-1,2,3-triazol-4-carbonsaeure-methylester 
• 57362-82-0 1-Methyl-1,2,3-triazol-4-carbonsaeure-methylester 
• 106308-44-5 rufinamide 
• 41086-74-2 2-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4-methoxycarbonyl-1,2,3-triazole 
• 31843-61-5 methyl 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-v-triazole-4-carboxylate 
• 62289-79-6 methyl 2-phenyl-2H-1,2,3-triazole-4-carboxylate 
• 2055-52-9 methyl 1-phenyl-1H-1,2,3-triazole-4-carboxylate 

Relevant articles and documents

One-pot microwave-assisted solvent free synthesis of simple alkyl 1,2,3-triazole-4-carboxylates by using trimethylsilyl azide

A fast one-pot microwave-assisted solvent free synthesis of simple alkyl 1,2,3-triazole-4-carboxylate derivatives by 1,3-dipolar cycloaddition reactions with trimethylsilyl azide (Me3Si-N3) on the alkylpropiolates and DMAD in high yi

The synthesis of methyl triazole-4-carboxylate gold(I) complex and application on allene synthesis and alkyne hydration

The methyl 1H-1,2,3-triazole-4-carboxylate containing a strong electron-withdrawing group was developed and applied as a ligand for gold(I) cations. The resulting ester-triazole gold(I) complex was investigated for its efficiency in catalyzing allene synthesis and alkyne hydration, in which an excellent catalytic efficiency was observed with low catalyst loadings.

Design, synthesis, and antiviral activity of new 1H-1,2,3-triazole nucleoside ribavirin analogs

Ribavirin is a broad antiviral compound with demonstrated activity against herpes simplex virus (HSV), human immunodeficiency virus HIV-1, influenza virus, respiratory syncytial virus, and hepatitis C virus, among other viruses. However, routine clinical use of ribavirin is limited because this compound is considerably cytotoxic. Herein, we describe the design, synthesis, and antiviral activity of new nucleoside ribavirin analogs based on the following: (1) ring bioisosterism of a 1,2,4-triazole for a 1,2,3-triazole; (2) amide group exchange for other substituents, such as c-propyl, methyl carboxylate, or trifluoromethyl groups; and (3) the ribofuranose remained linked to the triazole ring. Compounds 5a-c were obtained with yields of 65-36 % and tested against Influenza A and HSV-1 replication as well as reverse transcriptase (RT) from human immunodeficiency virus type 1 (HIV-1 RT). Compound 5b (R = CO 2CH3) was the most effective analog, with IC50 values 14 and 3.8 μM for Influenza A and HIV-1 RT, respectively.

ZnO nanoparticles-mediated regioselective synthesis of methyl-iV-alkylated 1,2,3-triazole-4-carboxylates

The 1,2,3-triazoles are versatile synthetic intermediates of many biologically active compounds, and their N-1 substituted analogues are potential pharmaceutically important derivatives. In this study, an efficient regioselective N-alkylation reaction of