496841-09-9

Basic information

• Product Name: (2S,3R)-methyl 3-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxylate
• Synonyms: (2S,3R)-methyl 3-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxylate;(3R)-3-Hydroxy-L-proline methyl ester trifluoroacetate;(2S,3R)-3-Hydroxy-2-pyrrolidinecarboxylic acid Methyl ester
• CAS NO: 496841-09-9
• Molecular Formula: C8H10F3NO4
• Molecular Weight: 241.164
• Mol File: 496841-09-9.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 247.2°C at 760 mmHg
• Flash Point: 103.3°C
• Appearance: /
• Density: 1.216g/cm³
• Vapor Pressure: 0.00426mmHg at 25°C
• Refractive Index: 1.487
• Storage Temp.: 2-8°C
• CAS DataBase Reference: (2S,3R)-methyl 3-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3R)-methyl 3-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxylate(496841-09-9)
• EPA Substance Registry System: (2S,3R)-methyl 3-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxylate(496841-09-9)

Safety Data

• Hazardous Substances Data: 496841-09-9(Hazardous Substances Data)

Usage

General Description

The chemical compound (2S,3R)-methyl 3-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxylate is a complex molecule with a specific stereochemistry. It consists of a pyrrolidine ring with a hydroxy group and a methyl ester attached to it. Additionally, it contains a trifluoroacetyl group, which is a derivative of acetic acid. (2S,3R)-methyl 3-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxylate has potential applications in pharmaceuticals and organic synthesis due to its unique structure and functional groups. Its specific stereochemistry is important, as it can influence the compound's biological activity and interactions with other molecules. Overall, the (2S,3R)-methyl 3-hydroxy-1-(2,2,2-trifluoroacetyl)pyrrolidine-2-carboxylate is a versatile and potentially valuable chemical compound with various potential uses in the field of chemistry and medicine.

InChI:InChI=1/C6H11NO3/c1-10-6(9)5-4(8)2-3-7-5/h4-5,7-8H,2-3H2,1H3/t4-,5+/m1/s1

Upstream product

• 76-05-1 trifluoroacetic acid 
• 184046-78-4 (2S,3S)-1-tert-butyl-2-methyl 3-hydroxypyrrolidine-1,2-dicarboxylate 
• 1844898-16-3 (2S,3S)-3-hydroxy-pyrrolidine-2-carboxylic acid methyl ester hydrochloride 
• 496841-07-7 (2S,3R)-N-tert-Butyloxycarbonyl-3-benzoyloxy-2-pyrrolidinecarboxylic Acid Methyl Ester 
• 130966-46-0 (2S,3R)-N-tert-Butyloxycarbonyl-3-hydroxy-2-pyrrolidinecarboxylic Acid Methyl Ester 
• 217447-51-3 C₃₀H₄₄N₂O₉Si 
• 217447-49-9 Methyl (2R,3R)-5,5-dimethoxy-2-[N,N'-(dibenzylcarbonylhydrazino)]-3-hydroxypentanoate 
• 217447-41-1 methyl 5,5-dimethoxy-3-oxo-4-pentanoate 
• 217447-47-7 (R)-3-Hydroxy-5,5-dimethoxy-pentanoic acid methyl ester 
• 217447-52-4 (2R,3R)-2-Amino-3-(tert-butyl-dimethyl-silanyloxy)-5,5-dimethoxy-pentanoic acid methyl ester 

Relevant articles and documents

Discovery of potent, orally-active, and muscle-selective androgen receptor modulators based on an N-aryl-hydroxybicyclohydantoin scaffold

A novel, N-aryl-bicyclohydantoin selective androgen receptor modulator scaffold was discovered through structure-guided modifications of androgen receptor antagonists. A prototype compound (7R,7aS)-10b from this series is a potent and highly tissue-selective agonist of the androgen receptor. After oral dosing in a rat atrophied levator ani muscle model, (7R,7aS)-10b demonstrated efficacy at restoring levator ani muscle mass to that of intact controls and exhibited >50-fold selectivity for muscle over prostate.

Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators

Replacement of the 3-oxo group of 2-chloro-4-[(7R,7aS)-7-hydroxy-1,3-dioxotetrahydro-1H-pyrrolo[1,2c]imidazol-2(3H)-yl]-3-methylbenzonitrile resulted in a sulfamide series of selective androgen receptor modulator (SARM) agonists.