497159-99-6

Basic information

• Product Name: Propanedioic acid, [[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-[(4-methyl phenyl)sulfonyl]-1H-imidazol-4-yl]-, dimethyl ester
• CAS NO: 497159-99-6
• Molecular Formula: C26H30N4O8S
• Molecular Weight: 558.612
• Mol File: 497159-99-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, [[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-[(4-methyl phenyl)sulfonyl]-1H-imidazol-4-yl]-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, [[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-[(4-methyl phenyl)sulfonyl]-1H-imidazol-4-yl]-, dimethyl ester(497159-99-6)
• EPA Substance Registry System: Propanedioic acid, [[6-[[(1,1-dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl][1-[(4-methyl phenyl)sulfonyl]-1H-imidazol-4-yl]-, dimethyl ester(497159-99-6)

Safety Data

• Hazardous Substances Data: 497159-99-6(Hazardous Substances Data)

Upstream product

• 497159-97-4 methyl {1-[(4-methylphenyl)sulfonyl]-1H-imidazol-4-yl}acetate 
• 51718-80-0 methyl 2-(1H-imidazol-4-yl)acetate hydrochloride 
• 3251-69-2 imidazole-4-acetic acid hydrochloride 
• 304873-96-9 (5-bromomethyl-pyridin-2-yl)-carbamic acid tert-butyl ester 
• 497159-98-5 dimethyl 2-{1-[(4-methylphenyl)sulfonyl]-1H-imidazol-4-yl}malonate 
• 199296-40-7 2-(tert-butyloxycarbonyl)-aminopyridine-5-carboxaldehyde 
• 169280-83-5 (5-hydroxymethylpyridin-2-yl)-carbamic acid t-butyl ester 

Downstream Products

• 1027056-58-1 3-(6-amino-pyridin-3-yl)-2-(1-benzyl-1H-imidazol-4-yl)-propionic acid ethyl ester 

Relevant articles and documents

IMIDAZOLE DERIVATIVES USED AS TAFIA INHIBITORS

The invention relates to compounds of formula (I), which are inhibitors of the activated thrombin-activatable fibrinolysis inhibitor. The compounds of formula (I) are suited for producing medicaments for the prevention and treatment of diseases accompanied by thromboses, embolisms, hypercoagulability or fibrotic changes.

Synthesis and Evaluation of Imidazole Acetic Acid Inhibitors of Activated Thrombin-Activatable Fibrinolysis Inhibitor as Novel Antithrombotics

Thrombin-activatable fibrinolysis inhibitor (TAFI) is an important regulator of fibrinolysis, and inhibitors of this enzyme have potential use in antithrombotic and thrombolytic therapy. Appropriately substituted imidazole acetic acids such as 10j were fo