49721-45-1 Usage
Description
4,5,6-Triaminopyrimidine sulfate is an organic compound with the chemical formula C5H9N5SO4. It is a white to light brown solid and is known for its role in the synthesis of various biologically active molecules, particularly those involving the incorporation of the adenine base. 4,5,6-Triaminopyrimidine sulfate has been converted to 4,5,6-triaminopyrimidine sulfite through formylation with C13 labeled formic acid, which is utilized in the preparation of adenine labeled with C13.
Uses
Used in Pharmaceutical Industry:
4,5,6-Triaminopyrimidine sulfate is used as an intermediate compound for the synthesis of various pharmaceuticals, particularly those involving the adenine base. Its conversion to 4,5,6-triaminopyrimidine sulfite through formylation with C13 labeled formic acid allows for the preparation of adenine labeled with C13, which can be used in the development of radiopharmaceuticals and other therapeutic agents.
Used in Research and Development:
In the field of research and development, 4,5,6-triaminopyrimidine sulfate serves as a valuable compound for studying the synthesis and properties of adenine and its derivatives. The use of C13 labeled formic acid in the conversion process provides researchers with a tool to investigate the behavior of labeled adenine in biological systems, which can contribute to the understanding of various biochemical processes and the development of novel therapeutic strategies.
Used in Chemical Synthesis:
4,5,6-Triaminopyrimidine sulfate is also used as a starting material or building block in the chemical synthesis of various compounds, particularly those with potential applications in the pharmaceutical, agrochemical, and materials science industries. Its versatile chemical properties make it a valuable component in the development of new molecules with specific functionalities and desired properties.
Check Digit Verification of cas no
The CAS Registry Mumber 49721-45-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,9,7,2 and 1 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 49721-45:
(7*4)+(6*9)+(5*7)+(4*2)+(3*1)+(2*4)+(1*5)=141
141 % 10 = 1
So 49721-45-1 is a valid CAS Registry Number.
InChI:InChI=1/C4H7N5.H2O4S/c5-2-3(6)8-1-9-4(2)7;1-5(2,3)4/h1H,5H2,(H4,6,7,8,9);(H2,1,2,3,4)/p-2
49721-45-1Relevant articles and documents
Synthesis of carbon-11-labeled imidazopyridine- and purine-thioacetamide derivatives as new potential PET tracers for imaging of nucleotide pyrophosphatase/phosphodiesterase 1 (NPP1)
Gao, Mingzhang,Wang, Min,Zheng, Qi-Huang
, p. 1371 - 1375 (2016/02/19)
The target tracer carbon-11-labeled imidazopyridine- and purine-thioacetamide derivatives, N-(3-[11C]methoxy-4-methoxyphenyl)-2-((5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)thio)acetamide (3-[11C]4a) and N-(4-[11C]methoxy-3-methoxyphenyl)-2-((5-methoxy-3H-imidazo[4,5-b]pyridin-2-yl)thio)acetamide (4-[11C]4a); 2-((6-amino-9H-purin-8-yl)thio)-N-(3-[11C]methoxy-4-methoxyphenyl)acetamide (3-[11C]8a) and 2-((6-amino-9H-purin-8-yl)thio)-N-(4-[11C]methoxy-3-methoxyphenyl)acetamide (4-[11C]8a), were prepared by O-[11C]methylation of their corresponding precursors with [11C]CH3OTf under basic condition (2 N NaOH) and isolated by a simplified solid-phase extraction (SPE) method in 50-60% radiochemical yields based on [11C]CO2 and decay corrected to end of bombardment (EOB). The overall synthesis time from EOB was 23 min, the radiochemical purity was >99%, and the specific activity at end of synthesis (EOS) was 185-555 GBq/μmol.
