49830-37-7

Basic information

• Product Name: 1-Aminocyclopentane carbonitrile
• Synonyms: A80241;1-aminocyclopentanecarbonitrile(SALTDATA: HCl);Cyclopentanecarbonitrile,1-amino-;Irbint-A01
• CAS NO: 49830-37-7
• Molecular Formula: C₆H₁₀N₂
• Molecular Weight: 110.16
• Mol File: 49830-37-7.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 217°Cat760mmHg
• Flash Point: 85°C
• Appearance: /
• Density: 1.02g/cm³
• Vapor Pressure: 0.136mmHg at 25°C
• Refractive Index: 1.497
• Storage Temp.: 2-8°C(protect from light)
• PKA: 5.18±0.20(Predicted)
• CAS DataBase Reference: 1-Aminocyclopentane carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Aminocyclopentane carbonitrile(49830-37-7)
• EPA Substance Registry System: 1-Aminocyclopentane carbonitrile(49830-37-7)

Safety Data

• Hazardous Substances Data: 49830-37-7(Hazardous Substances Data)

Usage

General Description

1-Aminocyclopentane carbonitrile, also known as 1-cyano-1-aminocyclopentane, is a chemical compound with the molecular formula C6H10N2. It is a cyclic amine with a nitrile group attached to the cyclopentane ring. 1-Aminocyclopentane carbonitrile is used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active molecules. It can also act as a ligand in coordination chemistry and catalysis. Additionally, 1-Aminocyclopentane carbonitrile has been studied for its potential biological activities, including its role as a GABA uptake inhibitor and its anticancer properties. Overall, this chemical compound has applications in both synthetic chemistry and medicinal chemistry due to its unique structural features and potential pharmaceutical properties.

InChI:InChI=1/C6H10N2/c7-5-6(8)3-1-2-4-6/h1-4,8H2

Upstream product

• 120-92-3 cyclopentanone 
• 5117-85-1 1-hydroxycyclopentanecarbonitrile 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 1003-03-8 Cyclopentamine 
• 773837-37-9 sodium cyanide 
• 7664-41-7 ammonia 
• 64-17-5 ethanol 
• 7732-18-5 water 
• 151-50-8 potassium cyanide 
• 143-33-9 sodium cyanide 
• 67-64-1 acetone 

Downstream Products

• 915086-69-0 4-(4-imino-2-thioxo-1,3-diazaspiro[4.4]non-3-yl)-2-trifluoromethylbenzonitrile 
• 1265634-43-2 5-(4-chlorophenyl)-N-(1-cyanocyclopentyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide 
• 6636-92-6 1-anilinocyclopentanecarbonitrile 
• 74002-22-5 cyclopentanimine 
• 699-51-4 1,3-diazaspiro[4.4]nonane-2,4-dione 
• 10316-79-7 (1-aminocyclopentyl)methanol 
• 877273-12-6 N-(1-cyanocyclopentyl)-13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-10-carboxamide 
• 92398-48-6 1-aminocyclopentanecarboxylic acid hydrochloride 
• 194984-24-2 1-cyano-1-n-pentanoylaminocyclopentane 
• 17193-28-1 1-aminocyclopentane-1-carboxamide 
• 83521-99-7 cyclopentanespiro-4'-imidazolidine-2',5'-dithione 
• 91806-24-5 1-Benzoylamino-cyclopentylnitril 
• 52-52-8 1-amino-1-cyclopentanecarboxylic acid 

Relevant articles and documents

Total syntheses of (±)-massadine and massadine chloride

The total syntheses of the complex pyrrole-imidazole alkaloids (±)-massadine and (±)-massadine chloride is described using a carefully orchestrated sequence of manipulations on highly polar and structurally complex intermediates. Key to the completion of this synthetic endeavor was the exploration of a unique and chemoselective method to oxidize unprotected guanidines under aqueous conditions in air. This oxidation has been optimized and applied to a selection of spirocyclic guanidines of varying complexity. Additionally, the 3,7-epi analogues of these interesting natural products have been synthesized and fully characterized. Copyright

Titanium-Catalyzed Cyano-Borrowing Reaction for the Direct Amination of Cyanohydrins with Ammonia

α-Aminonitrile was an important building block in natural products and key intermedia in organic chemistry. Herein, the direct amination of cyanohydrins with the partner of ammonia to synthesis N-unprotected α-aminonitriles is developed. The reaction proceeds via titanium-catalyzed cyano-borrowing reaction, which features high atom economy and simple operation. A broad range of ketone or aldehyde cyanohydrins was tolerated with ammonia, and the N-unprotected α-aminonitriles were synthesis with moderate to high yields under mild reaction conditions.

Design and Synthesis of Fsp3-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

The exploration of innovative chemical space is a critical step in the early phases of drug discovery. Bis-spirocyclic frameworks occur in natural products and other biologically relevant metabolites and show attractive features, such as molecular compactness, structural complexity, and three-dimensional character. A concise approach to the synthesis of bis-spirocyclic-based compound libraries starting from readily available commercial reagents and robust chemical transformations has been developed. A number of novel bis-spirocyclic scaffold examples, as implemented in the European Lead Factory project, is presented.