49830-37-7

Basic information

• Product Name: 1-Aminocyclopentane carbonitrile
• Synonyms: A80241;1-aminocyclopentanecarbonitrile(SALTDATA: HCl);Cyclopentanecarbonitrile,1-amino-;Irbint-A01
• CAS NO: 49830-37-7
• Molecular Formula: C₆H₁₀N₂
• Molecular Weight: 110.16
• Mol File: 49830-37-7.mol
• Article Data: 25

Chemical Properties

• Boiling Point: 217°Cat760mmHg
• Flash Point: 85°C
• Appearance: /
• Density: 1.02g/cm³
• Vapor Pressure: 0.136mmHg at 25°C
• Refractive Index: 1.497
• Storage Temp.: 2-8°C(protect from light)
• PKA: 5.18±0.20(Predicted)
• CAS DataBase Reference: 1-Aminocyclopentane carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Aminocyclopentane carbonitrile(49830-37-7)
• EPA Substance Registry System: 1-Aminocyclopentane carbonitrile(49830-37-7)

Safety Data

• Hazardous Substances Data: 49830-37-7(Hazardous Substances Data)

Usage

General Description

1-Aminocyclopentane carbonitrile, also known as 1-cyano-1-aminocyclopentane, is a chemical compound with the molecular formula C6H10N2. It is a cyclic amine with a nitrile group attached to the cyclopentane ring. 1-Aminocyclopentane carbonitrile is used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active molecules. It can also act as a ligand in coordination chemistry and catalysis. Additionally, 1-Aminocyclopentane carbonitrile has been studied for its potential biological activities, including its role as a GABA uptake inhibitor and its anticancer properties. Overall, this chemical compound has applications in both synthetic chemistry and medicinal chemistry due to its unique structural features and potential pharmaceutical properties.

InChI:InChI=1/C6H10N2/c7-5-6(8)3-1-2-4-6/h1-4,8H2

Upstream product

• 151-50-8 potassium cyanide 
• 120-92-3 cyclopentanone 
• 64-17-5 ethanol 
• 7732-18-5 water 
• 7677-24-9 trimethylsilyl cyanide 
• 7664-41-7 ammonia 
• 5117-85-1 1-hydroxycyclopentanecarbonitrile 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 773837-37-9 sodium cyanide 
• 143-33-9 sodium cyanide 
• 67-64-1 acetone 
• 1003-03-8 Cyclopentamine 

Downstream Products

• 52-52-8 1-amino-1-cyclopentanecarboxylic acid 
• 194984-24-2 1-cyano-1-n-pentanoylaminocyclopentane 
• 6636-92-6 1-anilinocyclopentanecarbonitrile 
• 74002-22-5 cyclopentanimine 
• 699-51-4 1,3-diazaspiro[4.4]nonane-2,4-dione 
• 10316-79-7 (1-aminocyclopentyl)methanol 
• 1265634-43-2 5-(4-chlorophenyl)-N-(1-cyanocyclopentyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide 
• 877273-12-6 N-(1-cyanocyclopentyl)-13-cyclohexyl-7H-indolo[2,1-a][2]benzazepine-10-carboxamide 
• 92398-48-6 1-aminocyclopentanecarboxylic acid hydrochloride 
• 915086-69-0 4-(4-imino-2-thioxo-1,3-diazaspiro[4.4]non-3-yl)-2-trifluoromethylbenzonitrile 
• 17193-28-1 1-aminocyclopentane-1-carboxamide 
• 83521-99-7 cyclopentanespiro-4'-imidazolidine-2',5'-dithione 
• 91806-24-5 1-Benzoylamino-cyclopentylnitril 

Relevant articles and documents

Total syntheses of (±)-massadine and massadine chloride

The total syntheses of the complex pyrrole-imidazole alkaloids (±)-massadine and (±)-massadine chloride is described using a carefully orchestrated sequence of manipulations on highly polar and structurally complex intermediates. Key to the completion of this synthetic endeavor was the exploration of a unique and chemoselective method to oxidize unprotected guanidines under aqueous conditions in air. This oxidation has been optimized and applied to a selection of spirocyclic guanidines of varying complexity. Additionally, the 3,7-epi analogues of these interesting natural products have been synthesized and fully characterized. Copyright

Photoreactive fused aziridinylpiperazines on the background of 4-substituted chalcones and their benzimidazolic analogs

The reaction of bromo-substituted chalcones with various diamino-compounds leads to the fused heterocyclic products, aziridinylpiperazines, exhibiting photoreactivity in the crystalline state. Crystals of 4-nitrosubstituted compounds of this family change their color from yellowish to deep violet-blue, 4-cyanosubstituted ones – from yellowish to pink at UV irradiation. Discussion on the mechanism of this phototransformation is still in progress, however, several facts points to the free radial nature of the photogenerated colored semi-products stabilized only by crystalline state of the irradiated samples. Formation of a mixture of positional isomers at interaction of bromo-chalcones with asymmetric diamines of aliphatic/alicyclic or aromatic series at synthesis of the title compounds is of significant interest as well.

A Sustainable, Semi-Continuous Flow Synthesis of Hydantoins

Hydantoins are an important class of heterocycles with applications in pharmacy, agriculture, and as intermediates in organic synthesis. Traditional synthetic procedures to access hydantoins are target oriented with multiple synthetic steps and often use reagents that are not commercially available or sustainable. Herein, an efficient process is described for accessing hydantoins starting from commercially available amines using consecutive gas–liquid transformations (oxygen, carbon dioxide). This semi-continuous process produced ten benzylic/aliphatic hydantoins in good overall yields (52–84 %).