49873-11-2

Basic information

• Product Name: 5-[(4-Benzyloxy)benzyl]-2,4-diaminopyrimidine
• Synonyms: 5-[(4-Benzyloxy)benzyl]-2,4-diaminopyrimidine
• CAS NO: 49873-11-2
• Molecular Formula: C₁₈H₁₈N₄O
• Molecular Weight: 306.36172
• Mol File: 49873-11-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 575.1°C at 760 mmHg
• Flash Point: 301.6°C
• Appearance: /
• Density: 1.252g/cm³
• Vapor Pressure: 3.14E-13mmHg at 25°C
• Refractive Index: 1.67
• CAS DataBase Reference: 5-[(4-Benzyloxy)benzyl]-2,4-diaminopyrimidine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(4-Benzyloxy)benzyl]-2,4-diaminopyrimidine(49873-11-2)
• EPA Substance Registry System: 5-[(4-Benzyloxy)benzyl]-2,4-diaminopyrimidine(49873-11-2)

Safety Data

• Hazardous Substances Data: 49873-11-2(Hazardous Substances Data)

Usage

General Description

5-[(4-Benzyloxy)benzyl]-2,4-diaminopyrimidine is a chemical compound that belongs to the class of pyrimidines. It consists of a pyrimidine ring with two amino groups and a benzyl group attached to the second carbon atom. The benzyl group is further substituted with a benzyloxy group, giving the compound its unique structure. This chemical can be used in pharmaceutical research and drug development due to its potential therapeutic properties, including its ability to interact with various biological targets. Its molecular structure and properties make it a potential candidate for further studies in the field of medicinal chemistry.

InChI:InChI=1/C18H18N4O/c19-17-15(11-21-18(20)22-17)10-13-6-8-16(9-7-13)23-12-14-4-2-1-3-5-14/h1-9,11H,10,12H2,(H4,19,20,21,22)

Upstream product

• 116168-96-8 (Z)-2-(4-Benzyloxy-benzyl)-3-morpholin-4-yl-acrylonitrile 
• 4397-53-9 p-benzyloxybenzaldehyde 
• 650606-20-5 5-[4-(tetrahydro-pyran-2-yloxy)-benzyl]-pyrimidine-2,4-diamine 
• 650606-19-2 (E)-2-(ethoxymethyl)-3-[4-(tetrahydro-2-pyranyloxy)phenyl]-2-propenenitrile 
• 123-08-0 4-hydroxy-benzaldehyde 
• 74189-56-3 4-(tetrahydropyran-2-yloxy)benzaldehyde 
• 100-39-0 benzyl bromide 
• 30077-67-9 2,4-diamino-5-(4-hydroxybenzyl)pyrimidine 
• 30077-74-8 3-anilino-2-<4-(benzyloxy)benzyl>acrylonitrile 
• 50-01-1 guanidine hydrochloride 

Downstream Products

• 30077-67-9 2,4-diamino-5-(4-hydroxybenzyl)pyrimidine 

Relevant articles and documents

2,4-Diaminopyrimidines as inhibitors of leishmanial and trypanosomal dihydrofolate reductase

This paper describes the synthesis of 4′-substituted and 3′,4′-disubstituted 5-benzyl-2,4-diaminopyrimidines as selective inhibitors of leishmanial and trypanosomal dihydrofolate reductase. Compounds were then assayed against the recombinant parasite and human enzymes. Some of the compounds showed good activity. They were also tested against the intact parasites using in vitro assays. Good activity was found against Trypanosoma cruzi, moderate activity against Trypanosoma brucei and Leishmania donovani. Molecular modeling was undertaken to explain the results. The leishmanial enzyme was found to have a more extensive lipophilic binding region in the active site than the human enzyme. Compounds which bound within the pocket showed the highest selectivity.

2,4-Diamino-5-benzylpyrimidines as antibacterial agents. 7. Analysis of the effect of 3,5-dialkyl substituent size and shape on binding to four different dihydrofolate reductase enzymes

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