501421-81-4

Basic information

• Product Name: (R,S)-6-[(4-chlorophenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-(3-hydroxy-3-methylbutyn-1-yl)-phenyl)-1-methyl-1H-quinolin-2-one
• CAS NO: 501421-81-4
• Molecular Weight: 538.046
• Mol File: 501421-81-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R,S)-6-[(4-chlorophenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-(3-hydroxy-3-methylbutyn-1-yl)-phenyl)-1-methyl-1H-quinolin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (R,S)-6-[(4-chlorophenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-(3-hydroxy-3-methylbutyn-1-yl)-phenyl)-1-methyl-1H-quinolin-2-one(501421-81-4)
• EPA Substance Registry System: (R,S)-6-[(4-chlorophenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-(3-hydroxy-3-methylbutyn-1-yl)-phenyl)-1-methyl-1H-quinolin-2-one(501421-81-4)

Safety Data

• Hazardous Substances Data: 501421-81-4(Hazardous Substances Data)

Upstream product

• 152120-66-6 5-(tert-Butyl-dimethyl-silanyl)-1-methyl-1H-imidazole 
• 1003-21-0 5-bromo-N-methylimidazole 
• 122-04-3 4-nitro-benzoyl chloride 
• 108-90-7 chlorobenzene 
• 7497-60-1 (4-Chlorophenyl)(4-nitrophenyl)methanone 
• 190898-64-7 2-(4-Chlorophenyl)-2-(4-nitrophenyl)-1,3-dioxolane 
• 501421-82-5 6-(4-chlorobenzoyl)-4-(3-bromo-phenyl)-1-methyl-1H-quinolin-2-one 

Downstream Products

• 439153-64-7 6-[(4-chlorophenyl)-hydroxy-(3-methyl-3H-imidazol-4-yl)-methyl]-4-(3-ethynylphenyl)-1-methyl-1H-quinolin-2-one 

Relevant articles and documents

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As part of a fast-paced oncology program, quinolinone 1 was discovered and developed as a potent inhibitor of farnesyl transferase for the treatment of cancer. The initial synthesis, which suffered from a lengthy linear sequence and a late-stage chromatog