502925-12-4

Basic information

• Product Name: 1H-Benzimidazole, 1-(4-bromophenyl)-
• CAS NO: 502925-12-4
• Molecular Formula: C13H9BrN2
• Molecular Weight: 273.132
• Mol File: 502925-12-4.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 1H-Benzimidazole, 1-(4-bromophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Benzimidazole, 1-(4-bromophenyl)-(502925-12-4)
• EPA Substance Registry System: 1H-Benzimidazole, 1-(4-bromophenyl)-(502925-12-4)

Safety Data

• Hazardous Substances Data: 502925-12-4(Hazardous Substances Data)

Usage

Structure

A chemical compound containing a benzimidazole ring and a bromophenyl group attached to the benzimidazole ring.

Type

Derivative of benzimidazole

Industrial and pharmaceutical applications

Used as a building block in the synthesis of various pharmaceuticals, agrochemicals, and functional materials.

Biological activities

Known for its antitumor, antibacterial, and antifungal properties, making it a valuable compound in drug discovery and development.

Materials science potential

Has been studied for its potential use in the development of organic light-emitting diodes (OLEDs) and other optoelectronic devices.

Upstream product

• 51-17-2 benzoimidazole 
• 65826-67-7 bis(4-bromophenyl)iodonium bromide 
• 106-37-6 1.4-dibromobenzene 
• 583-39-1 2,3-dihydrobenzimidazol-2-thione 
• 5467-74-3 4-Bromophenylboronic acid 
• 460-00-4 1-Bromo-4-fluorobenzene 
• 589-87-7 1,4-bromoiodobenzene 

Downstream Products

• 1104736-29-9 1-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-1H-benzoimidazole 
• 1402749-01-2 1-(4-(1H-pyrazol-1-yl)phenyl)-1H-benzo[d]imidazole 
• 1402748-99-5 1-(4-(phenylethynyl)phenyl)-1H-benzo[d]imidazole 
• 85346-51-6 1-([1,1'-biphenyl]-4-yl)-1H-benzo[d]imidazole 
• 1345685-93-9 2-(2-{[4-(1H-benzimidazol-1-yl)phenyl]amino}ethoxy)ethanol 

Relevant articles and documents

Using silyl protecting group to enable post-deposition C-C coupling reactions of alkyne-functionalized N-heterocyclic carbene monolayers on Au surfaces

N-Heterocyclic carbenes (NHCs) were functionalized with a triisopropylsilyl (TIPS)-protected alkyne group and self-assembled on Au films to enable post-deposition functionalization by C-C coupling reactions. The TIPS group efficiently protected the alkyne and prevented its deprotonation during surface-anchoring of NHC. Sonogashira C-C coupling reactions were performed on the Au film in high yield following removal of the TIPS group, demonstrating that post-deposition coupling reactions can be employed to widen the chemical scope of surface-anchored NHCs. This journal is

A Chemoselective and Desulfurative Chan–Lam Coupling: C–N Bond Formation between Benzimidazoline-2-Thiones and Arylboronic Acids

An efficient method for the chemoselective and desulfurative Chan–Lam cross-coupling based on benzimidazoline-2-thiones was developed. By modulating the amount of the catalyst Cu(OAc)2·H2O, alkali, temperature, and solvent, the desulfurizational C–N bond formation product (N-arylbenzimidazoles) could be selectively furnished smoothly. The features of this protocol are an inexpensive and readily available catalyst, ligand-free conditions, wide substrate scope, easy performance, and moderate to excellent yields. It shows potential synthetic value for the preparation of a diversity of arylbenzoheterocyclic compounds, which are potentially active in pharmaceuticals and agrochemicals.

Discovery of novel non-steroidal cytochrome p450 17a1 inhibitors as potential prostate cancer agents

The current study presents the design, synthesis, and evaluation of novel cytochrome P450 17A1 (CYP17A1) ligands. CYP17A1 is a key enzyme in the steroidogenic pathway that produces androgens among other steroids, and it is implicated in prostate cancer. T