503-87-7 Usage
Description
2-Thiohydantoin is an organic compound that serves as a versatile synthetic intermediate in the pharmaceutical and chemical industries. It is a brown crystalline powder with unique chemical properties that make it suitable for various applications.
Uses
Used in Pharmaceutical Industry:
2-Thiohydantoin is used as a reactant for the synthesis of drugs with antidiabetic activity, helping to develop medications that can manage and treat diabetes.
Used in Antimicrobial Applications:
In the pharmaceutical industry, 2-Thiohydantoin is also used as a reactant for the synthesis of barbituric acid and thiohydantoin derivatives with antimicrobial activity, contributing to the development of antibiotics and antifungal agents.
Used in Anticancer Applications:
2-Thiohydantoin is used as a reactant for the synthesis of possible anticancer agents, playing a role in the development of new treatments for cancer.
Used in Fibroblast Growth Factor Receptor 1 Kinase Inhibitors:
2-Thiohydantoin is used as a reactant for the synthesis of fibroblast growth factor receptor 1 kinase inhibitors, which are important in the treatment of various diseases, including cancer.
Used in HIV-1 Integrase Inhibitors:
In the pharmaceutical industry, 2-Thiohydantoin is used as a reactant for the synthesis of HIV-1 integrase inhibitors, which are crucial in the development of antiretroviral drugs for the treatment of HIV/AIDS.
Used in Chemical Industry:
2-Thiohydantoin is used as a reactant for persilylation, a chemical process that involves the introduction of a silyl group into a molecule, which is important in various chemical reactions and synthesis.
Check Digit Verification of cas no
The CAS Registry Mumber 503-87-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,0 and 3 respectively; the second part has 2 digits, 8 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 503-87:
(5*5)+(4*0)+(3*3)+(2*8)+(1*7)=57
57 % 10 = 7
So 503-87-7 is a valid CAS Registry Number.
InChI:InChI=1/C3H4N2OS/c6-2-1-4-3(7)5-2/h1H2,(H2,4,5,6,7)
503-87-7Relevant articles and documents
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Congdon,Edward
, p. 3780,3783 (1972)
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A simple synthesis of 2-thiohydantoins
Wang, Zerong Daniel,Sheikh, Samia O.,Zhang, Yulu
, p. 739 - 750 (2006)
2-Thiohydantoin derivatives are produced by heating a mixture of thiourea and an a-amino acid. The method described offers the advantages of simplicity, low cost, easy work-up and scalability.
Utility of 3-(thiophen-2-yl)prop-2-enoyl isothiocyanate in heterocyclic synthesis
El-Sayed, Amira A,Atta-Allah, Saad R,Hemdan, Magdy M
, p. 307 - 312 (2019/07/19)
Convenient syntheses of quinazoline, benzothiazole, thiadiazole, imidazole, and thiourea derivatives starting from 3-(thiophen-2-yl)prop-2-enoyl isothiocyanate are described. The structures of the synthesized compounds are confirmed from their microanalytical and spectral data. Some of the products are examined for their antibacterial activity against Gram-positive and Gram-negative bacteria and fungi.
Compound capable of inhibiting activity of NEDD8 kinase as well as preparation method and pharmaceutical application of compound
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Paragraph 0082; 0083; 0084, (2016/10/10)
The invention belongs to the field of medicines and in particular relates to a compound with the structure of a formula I, a stereomer of the compound or pharmaceutically acceptable salts of the compound as well as a preparation method of the compound and application of the compound to preparation of anti-tumor medicines. A pharmacological experiment result shows that the compound can be used for inhibiting the activity of NEDD8 kinase and has the inhibition effect on proliferation of a plurality of types of tumor cells, so that the compound can be used as an NEDD8 kinase activity inhibitor for preparing the anti-tumor medicines. The formula I is shown in the description.