503437-19-2

Basic information

• Product Name: 2,6-DICHLORO-4-TRIFLUOROMETHYL-NICOTINIC ACID
• Synonyms: 2,6-DICHLORO-4-TRIFLUOROMETHYL-NICOTINIC ACID;IFLAB-BB F2108-0098;RARECHEM AL BO 0730;2,6-dichloro-4-(trifluoromethyl)pyridine-3-carboxylic acid;2,6-Dichloro-4-(trifluoromethyl)pyridine-3-carboxylic acid, 3-Carboxy-2,6-dichloro-4-(trifluoromethyl)pyridine
• CAS NO: 503437-19-2
• Molecular Formula: C₇H₂Cl₂F₃NO₂
• Molecular Weight: 260
• Mol File: 503437-19-2.mol
• Article Data: 4

Chemical Properties

• Melting Point: 79-80°
• Boiling Point: 318.132°C at 760 mmHg
• Flash Point: 146.201°C
• Appearance: /
• Density: 1.703
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.515
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,6-DICHLORO-4-TRIFLUOROMETHYL-NICOTINIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-DICHLORO-4-TRIFLUOROMETHYL-NICOTINIC ACID(503437-19-2)
• EPA Substance Registry System: 2,6-DICHLORO-4-TRIFLUOROMETHYL-NICOTINIC ACID(503437-19-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 503437-19-2(Hazardous Substances Data)

Usage

General Description

2,6-Dichloro-4-trifluoromethyl-nicotinic acid is a chemical compound with the molecular formula C8H3Cl2F3NO2. It is a chlorinated derivative of nicotinic acid and is used as a building block in the synthesis of pharmaceuticals and agrochemicals. 2,6-DICHLORO-4-TRIFLUOROMETHYL-NICOTINIC ACID is a white solid with a melting point of 207-209°C. It is also known for its herbicidal properties and is used in the development of herbicides to control weeds in agricultural crops. Additionally, it is used as an intermediate in the manufacturing of various compounds and has applications in the field of organic synthesis and research.

InChI:InChI=1/C7H2Cl2F3NO2/c8-3-1-2(7(10,11)12)4(6(14)15)5(9)13-3/h1H,(H,14,15)

Upstream product

• 158063-67-3 2,6-dichloro-4-trifluoromethyl-3-pyridine carboxamide 
• 13600-42-5 2,6-dichloro-4-(trifluoromethyl)pyridine-3-carbonitrile 
• 124-38-9 carbon dioxide 
• 39890-98-7 2,6-dichloro-4-(trifluoromethyl)pyridine 

Downstream Products

• 158063-66-2 4-(trifluoromethyl)nicotinic acid 

Relevant articles and documents

Preparation method and application of N-cyanomethyl bis(trifluoromethyl) nicotinamide

The invention discloses a preparation method of N-cyanomethyl bis(trifluoromethyl) nicotinamide. The preparation method is implemented according to the following steps of: by adopting 2, 6-dichloro-3-cyano-4-tirfluoromethyl pyridine as a material, carrying out nitrile-group hydrolysis, hydrogenolysis and amidation reaction, and finally preparing the N-cyanomethyl bis(trifluoromethyl) nicotinamide, wherein the filtrate generated in the amidation reaction can be used as a reaction solvent for amidation reaction again after heating filtration and cooling filtration to prepare the N-cyanomethyl bis(trifluoromethyl) nicotinamide. The N-cyanomethyl bis(trifluoromethyl) nicotinamide prepared by adopting the preparation method is 71.1-85.7% in yield and 99.1-99.9%, and can be applied as a standard product for detecting the content of flonicamid and calibrating the content of impurities in the preparation process. The preparation method is applicable to preparing the N-cyanomethyl bis(trifluoromethyl) nicotinamide and monitoring flonicamid.

Synthesis and Structure-Activity Relationships of Novel 7-Substituted 1,4-Dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acids as Antitumor Agents. Part 2

We have previously reported that a series of 7-substituted 6-fluoro-1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids possess moderate cytotoxic activity. In a further attempt to find clinically useful antitumor agents, we investigated the structure-activity relationships (SARs) of a new series of compounds obtained by changing the C-6 position of the fluorine atom in addition to the C-5 and C-7 positions and evaluating their cytotoxic activity against several murine and human tumor cell lines. Our results showed that the 6-unsubstituted 1,8-naphthyridine structure had the most potent cytotoxic activity against murine P388 leukemia twice that of the 6-fluoro analogue. In addition, introduction of an amino group at the C-5 position did not have any substantial effect on the cytotoxic activity, while both the 5-chloro and 5-trifluoromethyl groups decreased the cytotoxic activity by 5- to 10-fold. Moreover, aminopyrrolidine derivatives at the C-7 position showed more potent cytotoxic activity than other amines or carbon derivatives. Among the 7-(3-aminopyrrolidinyl) derivatives, the trans-3-methoxy-4-methylaminopyrrolidinyl derivative (271) was determined to have potent cytotoxic activity in both in vitro and in vivo assays and high water solubility. Finally, the (S,S)-isomer (AG-7352, 3) of 271, with a cytotoxic activity against human tumor cell lines more potent than that of etoposide, was selected for further development.