50373-76-7

Basic information

• Product Name: 5,5-bis(4-methylphenyl)imidazolidine-2,4-dione
• Synonyms: 2,4-imidazolidinedione, 5,5-bis(4-methylphenyl)-
• CAS NO: 50373-76-7
• Molecular Formula: C₁₇H₁₆N₂O₂
• Molecular Weight: 280.3211
• Mol File: 50373-76-7.mol
• Article Data: 6

Chemical Properties

• Density: 1.202g/cm³
• Refractive Index: 1.595
• CAS DataBase Reference: 5,5-bis(4-methylphenyl)imidazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 5,5-bis(4-methylphenyl)imidazolidine-2,4-dione(50373-76-7)
• EPA Substance Registry System: 5,5-bis(4-methylphenyl)imidazolidine-2,4-dione(50373-76-7)

Safety Data

• Hazardous Substances Data: 50373-76-7(Hazardous Substances Data)

Upstream product

• 611-97-2 bis(p-methylphenyl)-methanone 
• 151-50-8 potassium cyanide 
• 104-87-0 4-methyl-benzaldehyde 
• 1218-89-9 4,4'-dimethylbenzoin 
• 57-13-6 urea 
• 3457-48-5 1,2-di(4-methylphenyl)-1,2-ethanedione 
• 120-89-8 parabanic acid 
• 108-88-3 toluene 

Downstream Products

• 56079-97-1 3-[3-(4-hydroxy-4-phenyl-piperidin-1-yl)-propyl]-5,5-di-p-tolyl-imidazolidine-2,4-dione 
• 56079-89-1 3-[3-(4-phenyl-piperidin-1-yl)-propyl]-5,5-di-p-tolyl-imidazolidine-2,4-dione 
• 309253-29-0 N-diphenylmethyl-N'-[1,1-bis(4-methylphenyl)-1-(methoxycarbonyl)methyl]sulfamide 
• 309253-27-8 N-tert-butyl-N'-[1,1-bis(4-methylphenyl)-1-(methoxycarbonyl)methyl]sulfamide 
• 309253-14-3 amino-di-p-tolyl-acetic acid methyl ester 
• 309253-56-3 amino-di-p-tolyl-acetic acid 

Relevant articles and documents

Magnetic magnetite nanoparticals catalyzed selective oxidation of Α-hydroxy ketones with air and one-pot synthesis of benzilic acid and phenytoin derivatives

A clean and efficient protocol for selective oxidation of α-hydroxy ketones using magnetic magnetite nanoparticals (Fe3O4·MNPs) as catalyst with air as green oxidant has been developed. Application of Fe3O4·MNPs was also proved to be successful in one-pot synthesis of benzilic acid and phenytoin derivatives. The facile one-pot procedure enhanced the production efficiency, shortened the reaction time and minimized the chemical waste. Notably, the catalyst can be reused at least for five times without any appreciable loss of its activity.

One-pot synthesis of phenytoin analogs

A series of phenytoin analogs (5,5-diphenylimidazolidine-2,4-dione or 5,5-diphenyl-hydantoin) were synthesized in 65-75% yield from the corresponding substituted benzils. The same products were also obtained directly from α-hydroxy ketones via one-pot procedure.

3-alkyl-(5,5'-diphenyl)imidazolidinediones as new cannabinoid receptor ligands

Twenty-four 3-alkyl-(5,5'-diphenyl)imidazolidinediones were synthesized and evaluated as new cannabinoid receptor ligands. Three compounds exhibited a Ki value around 100 nM against [3H]-SR 141716A binding obtained from human CB1 transfected CHO cells membranes. The lack of change of affinity in the presence of a non hydrolyzable GTP analogue seems to indicate they are cannabinoid antagonists.