50675-21-3

Basic information

• Product Name: 1-METHYLPIPERIDINE-4-CARBALDEHYDE
• Synonyms: 1-METHYLPIPERIDINE-4-CARBALDEHYDE;CHEMBRDG-BB 4017912;1-Methyl-4-piperidinecarboxaldehyde;1-methyl-4-piperidinecarboxyaldehyde;1-methylpiperidine-4-carbaldehyde(SALTDATA: FREE);1-METHYLPIPERIDINE-4-CARBALDEH
• CAS NO: 50675-21-3
• Molecular Formula: C₇H₁₃NO
• Molecular Weight: 127.18
• Mol File: 50675-21-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 173℃
• Flash Point: 53℃
• Appearance: /
• Density: 1.024
• Vapor Pressure: 1.286mmHg at 25°C
• Refractive Index: 1.524
• PKA: 8.61±0.10(Predicted)
• CAS DataBase Reference: 1-METHYLPIPERIDINE-4-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYLPIPERIDINE-4-CARBALDEHYDE(50675-21-3)
• EPA Substance Registry System: 1-METHYLPIPERIDINE-4-CARBALDEHYDE(50675-21-3)

Safety Data

• Hazardous Substances Data: 50675-21-3(Hazardous Substances Data)

Usage

General Description

1-Methylpiperidine-4-carbaldehyde is a chemical compound with the molecular formula C8H13NO, which is commonly used in the production of pharmaceuticals and agrochemicals. It is a colorless to pale yellow liquid with a pungent odor, and it is primarily used as an intermediate in the synthesis of various compounds. This chemical is considered to be a versatile building block in organic chemistry due to its ability to react with a wide range of reagents. It is important to handle 1-Methylpiperidine-4-carbaldehyde with caution, as it is considered to be a hazardous and flammable substance. Additionally, this compound has been found to have potential impacts on human health and the environment, and therefore should be used and stored in accordance with proper safety protocols and regulations.

InChI:InChI=1/C7H13NO/c1-8-4-2-7(6-9)3-5-8/h6-7H,2-5H2,1H3

Upstream product

• 1690-75-1 1-methyl-piperidine-4-carboxylic acid methyl ester 
• 498-94-2 isonipecotic acid 
• 24252-37-7 ethyl 1-methylisonipecotate 
• 58795-05-4 4-(1,3-dioxolan-2-yl)-1-methylpyridinium iodide 
• 61379-59-7 4-[1,3]dioxolan-2-yl-pyridine 
• 872-85-5 pyridine-4-carbaldehyde 
• 71985-80-3 1-methylpiperidine-4-carboxylic acid hydrochloride 
• 112391-04-5 4-(1,3-dioxolan-2-yl)-1-methylpiperidine 
• 694-55-3 N-methyl-3,4-didehydropiperidine 
• 201230-82-2 carbon monoxide 
• 1445-73-4 1-Methyl-4-piperidone 

Downstream Products

• 10333-64-9 1-methyl-4 (formylmethyl)piperidine 
• 1191255-73-8 C₂₄H₃₁N₅O₂ 
• 1383539-74-9 2-(2,5-dimethyl-benzylsulfanyl)-4-(1-methyl-piperidin-4-yl)-6-oxo-1,6-dihydro-pyrimidine-5-carbonitrile 
• 111725-58-7 11-(γ-aminopropyl)-3-methyl-3,7,11-triazaspiro<5,6>dodecane 
• 90703-74-5 3-methyl-3,7,11-triazaspiro<5,6>dodecane 
• 90703-73-4 9-methyl-1,4,9-triazaspiro<5,5>undecane 

Relevant articles and documents

Ligand-biased and probe-dependent modulation of chemokine receptor CXCR3 signaling by negative allosteric modulators

Over the last decade, functional selectivity (or ligand bias) has evolved from being a peculiar phenomenon to being recognized as an essential feature of synthetic ligands that target G protein-coupled receptors (GPCRs). The CXC chemokine receptor 3 (CXCR3) is an outstanding platform to study various aspects of biased signaling, because nature itself uses functional selectivity to manipulate receptor signaling. At the same time, CXCR3 is an attractive therapeutic target in the treatment of autoimmune diseases and cancer. Herein we report the discovery of an 8-azaquinazolinone derivative (N-{1-[3-(4-ethoxy-phenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl]ethyl}-4-(4-fluorobutoxy)-N-[(1-methylpiperidin-4-yl)methyl]butanamide, 1b) that can inhibit CXC chemokine 11 (CXCL11)-dependent G protein activation over β-arrestin recruitment with 187-fold selectivity. This compound also demonstrates probe-dependent activity, that is, it inhibits CXCL11- over CXCL10-mediated G protein activation with 12-fold selectivity. Together with a previously reported biased negative allosteric modulator from our group, the present study provides additional information on the molecular requirements for allosteric modulation of CXCR3.

Anti-hypertensive piperidine compounds

Novel compounds of the formula: STR1 are described wherein Z is a bicyclic aryl group containing between 9 and 10 ring atoms, up to two of which may be nitrogen and up to one of which may be oxygen or sulfur; A is an ethenyl group which may be lower-alkyl-substituted; and R and R' each represent H or an aliphatic group of 1-4 carbon atoms; or a pharmaceutically acceptable acid addition salt thereof.

Synthesis of 1'-Methylspiro from 1-Methyl-n-piperidinecarbaldehydes

1'-Methylspiro 2 can be obtained from 1-methyl-n-piperidinecarbaldehydes 1 by the Fischer reaction of their phenylhydrazones.The Fischer reaction provides different kinds of products -3H-indole, indole and oxindole- which depend on the N atom position in the piperidine ring.