50794-17-7

Basic information

• Product Name: ethyl β-(o-Nitrobenzylamino)-propionate
• Synonyms: ethyl β-(o-Nitrobenzylamino)-propionate
• CAS NO: 50794-17-7
• Molecular Weight: 252.27
• Mol File: 50794-17-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: ethyl β-(o-Nitrobenzylamino)-propionate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl β-(o-Nitrobenzylamino)-propionate(50794-17-7)
• EPA Substance Registry System: ethyl β-(o-Nitrobenzylamino)-propionate(50794-17-7)

Safety Data

• Hazardous Substances Data: 50794-17-7(Hazardous Substances Data)

Upstream product

• 24835-08-3 2-nitrobenzylamine hydrochloride 
• 140-88-5 ethyl acrylate 
• 552-89-6 2-nitro-benzaldehyde 
• 4244-84-2 ethyl β-alaninate hydrochloride 

Downstream Products

• 345201-61-8 3-[[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-(2-nitro-benzyl)-amino]-propionic acid ethyl ester 
• 345201-65-2 3-{(2-amino-benzyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-propionic acid ethyl ester 
• 345201-79-8 3-{[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-propionic acid 
• 345201-74-3 3-{[2-(2-{(2-tert-butoxycarbonylamino-ethyl)-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-acetylamino)-benzyl]-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-propionic acid ethyl ester 

Relevant articles and documents

Backbone modifications of aromatic peptide nucleic acid (APNA) monomers and their hybridization properties with DNA and RNA

Aromatic peptide nucleic acid (APNA) monomers containing N-(2-aminobenzyl)-glycine, N-(2-aminobenzyl)-(R)- or -(S)-alanine, and N-(2-aminobenzyl)-β-alanine moieties as part of their backbone were synthesized. These novel analogues were incorporated as a single "point mutation" in PNA hexamers, and their physicochemical properties were investigated by UV thermal denaturation and CD experiments. Destabilization in triplex formation between the PNA-APNA chimeras and complementary DNA or RNA oligomers was observed, as compared to the PNA control. The APNA monomer composed of the N-(2-aminobenzyl)-glycine backbone led to the smallest decrease in the thermal stability of the triplexes formed with DNA and RNA, while maintaining selectivity for base-pairing recognition. Since the PNA-APNA chimeras are more lipophilic than the corresponding PNA homopolymers, these oligomers may also exhibit better cell membrane permeability properties.

Optionally substituted 1,2,3,5-tetrahydroimidezo(2,1-b)-quinazolin-2-ones and 6(H)-1,2,3,4-tetrahydropyimido(2,1-b)quinazolin-2-ones

Optionally substituted 1,2,3,5-tetrahydroimidazo[2,1-b]-quinazolin-2-ones and 6-[H]-1,2,3,4-tetrahydropyrimido[2,1-b]-quinazolin-2-ones or the pharmaceutically acceptable salts thereof are compounds useful as blood platelet anti-aggregative and/or antihypertensive and/or bronchodilator agents in mammals, including humans.