50888-81-8

Basic information

• Product Name: Pyrrolidine, 1-(2-phenyl-1-propenyl)-
• CAS NO: 50888-81-8
• Molecular Formula: C13H17N
• Molecular Weight: 187.285
• Mol File: 50888-81-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Pyrrolidine, 1-(2-phenyl-1-propenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolidine, 1-(2-phenyl-1-propenyl)-(50888-81-8)
• EPA Substance Registry System: Pyrrolidine, 1-(2-phenyl-1-propenyl)-(50888-81-8)

Safety Data

• Hazardous Substances Data: 50888-81-8(Hazardous Substances Data)

Upstream product

• 74931-56-9 2-phenyl-1-(pyrrolidin-1-yl)propan-1-one 

Downstream Products

• 17429-36-6 4-methyl-4-phenylcyclohex-2-enone 
• 2042-85-5 1,2-diphenylpropan-1-one 
• 98-83-9 isopropenylbenzene 
• 123-75-1 pyrrolidine 
• 3760-54-1 1-pyrrolidinecarboxaldehyde 
• 54435-79-9 (Z)-1,3-diphenyl-2-buten-1-one 
• 98-86-2 acetophenone 

Relevant articles and documents

Cross-Coupling of Secondary Amides with Tertiary Amides: The Use of Tertiary Amides as Surrogates of Alkyl Carbanions for Ketone Synthesis

In recent years, exciting progress has been made in the field of direct transformation of amides, nevertheless, the condensation between two amides remains rare and restricted to homo-coupling reactions. Herein, we report the cross-coupling of secondary amides with tertiary amides, which provides a synthesis of ketones under mild conditions, and features the use of tertiary amides as surrogates of alkyl carbanions. The method relies on the coupling of enamines, generated from tertiary amides by catalytic partial reduction of tertiary amides with Vaska's catalyst, with nitrilium ions, formed in situ from secondary amides via activation with trifluoromethanesulfonic anhydride, and on the subsequent deformylation.