3760-54-1

Basic information

• Product Name: 1-FORMYLPYRROLIDINE
• Synonyms: TIMTEC-BB SBB008020;N-FORMYLPYRROLIDINE;PYRROLIDINE-1-CARBOXALDEHYDE;1-PYRROLIDINECARBOXALDEHYDE;1-FORMYLPYRROLIDINE;1-Pyrrolidinecarbaldehyde;pyrrolidine-1-carbaldehyde;prolinal
• CAS NO: 3760-54-1
• Molecular Formula: C₅H₉NO
• Molecular Weight: 99.13
• EINECS: 223-175-7
• Mol File: 3760-54-1.mol
• Article Data: 110

Chemical Properties

• Boiling Point: 92-94 °C15 mm Hg(lit.)
• Flash Point: 203 °F
• Appearance: clear slightly yellow liquid
• Density: 1.04 g/mL at 25 °C(lit.)
• Vapor Pressure: 2.71mmHg at 25°C
• Refractive Index: n20/D 1.479(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.44±0.20(Predicted)
• BRN: 106540
• CAS DataBase Reference: 1-FORMYLPYRROLIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-FORMYLPYRROLIDINE(3760-54-1)
• EPA Substance Registry System: 1-FORMYLPYRROLIDINE(3760-54-1)

Safety Data

• Safety Statements: 23-24/25
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 3760-54-1(Hazardous Substances Data)

Usage

Description

1-Formylpyrrolidine, a clear slightly yellow liquid, is a monomer constituent of gas clathrate inhibitors. It is an organic compound with the molecular formula C5H9NO, and it plays a significant role in the synthesis of various chemical compounds.

Uses

1. Used in Chemical Synthesis:
1-Formylpyrrolidine is used as a key intermediate in the synthesis of complex organic molecules. Its application in this field is due to its ability to react with other compounds to form new chemical entities with specific properties.
2. Used in the Synthesis of Silacyclopentane Derivatives:
1-Formylpyrrolidine is used as a building block for the synthesis of 1-oxa-3,4-dimethyl-5-(1-pyrrolldino)-2,2-di(tert-butyl)silacyclopentane and 1-oxa-4-isopropyl-5-(1-pyrrolidino)-2,2-di(tert-butyl)silacyclopentane. These silicyclopentane derivatives are important in the development of new materials and pharmaceuticals due to their unique structural and chemical properties.
3. Used in Gas Clathrate Inhibition:
1-Formylpyrrolidine is used as a monomer constituent in the development of gas clathrate inhibitors. Clathrate inhibitors are essential in the oil and gas industry to prevent the formation of gas hydrates, which can cause blockages in pipelines and other equipment. The use of 1-Formylpyrrolidine in this application is due to its ability to interact with other molecules and form stable clathrate structures, thus preventing the formation of unwanted gas hydrates.

InChI:InChI=1/C5H9NO/c7-4-5-2-1-3-6-5/h4-6H,1-3H2

Upstream product

• 123-75-1 pyrrolidine 
• 50-00-0 formaldehyd 
• 67-66-3 chloroform 
• 18197-22-3 N-formylformamide 
• 201230-82-2 carbon monoxide 
• 73722-93-7 C₆H₁₂NO⁽¹⁺⁾*CH₃O₄S^(1-) 
• 3411-58-3 L-cystein ethyl ester 
• 56176-56-8 E-1-pyrrolidino-1-butene 
• 5388-44-3 1-deoxy-1-prolino-D-fructose 
• 62453-13-8 Benzyl-[1-pyrrolidin-1-yl-meth-(E)-ylidene]-amine 
• 64-19-7 acetic acid 
• 50888-81-8 α-Methyl-β-pyrrolidino styrene 
• 4625-58-5 Bis(1-pyrrolidinyl)acetonitril 
• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 56951-49-6 1-[N-(5-nitro-[1,3,4]thiadiazol-2-yl)-formimidoyl]-pyrrolidine 
• 1257533-47-3 N'-(1,3-diphenyl-4-formyl-1H-pyrazol-5-yl)-N-pyrrolidinylmethanimidamide 
• 6030-36-0 4-methylthiophene-2-carbaldehyde 
• 5834-16-2 3-methyl-2-thiophenecarboxaldehdye 
• 3760-55-2 N-nitropyrrolidine 
• 7632-86-2 1-p-methoxyphenyl-3-pyrrolidino-2-propen-1-thione 
• 5564-73-8 1-(dimethoxymethyl)pyrrolidine 
• 85377-68-0 C₈H₆ClNOS 
• 1817-49-8 1,3-diphenyl-1-propyn-3-ol 
• 119141-10-5 2,4-dichloro-3-(pyrrolidinylmethylene)-1,4-cyclohexadiene-1,5-dicarboxaldehyde 
• 86869-55-8 C₉H₁₀N₂OS 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 58415-03-5 C₉H₉NOS 

Relevant articles and documents

Olefin functionalized IPr.HCl monomer as well as preparation method and application thereof

The invention relates to an olefin functionalized IPr.HCl monomer, a preparation method thereof, a method for preparing an N-heterocyclic carbene functionalized organic polymer (PS-IPr-x) by using the olefin functionalized IPr.HCl monomer, and application of the N-heterocyclic carbene functionalized organic polymer as a heterogeneous catalyst for catalyzing reduction N-formylation of carbon dioxide and amine. A heterogeneous catalyst is prepared by using cheap and easily available DVB as a polymerization cross-linking agent through an AIBN-initiated olefin polymerization method, and has the advantages of low preparation cost and simple preparation method. Meanwhile, the catalytic activity of the catalyst is obviously higher than that of reported catalysts, and the catalyst has a wide practical application prospect.

Nickel-Catalyzed Amination of Aryl Chlorides with Amides

A nickel-catalyzed amination of aryl chlorides with diverse amides via C-N bond cleavage has been realized under mild conditions. A broad substrate scope with excellent functional group tolerance at a low catalyst loading makes the protocol powerful for synthesizing various aromatic amines. The aryl chlorides could selectively couple to the amino fragments rather than the carbonyl moieties of amides. Our protocol complements the conventional amination of aryl chlorides and expands the usage of inactive amides.

Method for preparing formamide compound by using MCOF to catalyze CO2 as carbon source at normal temperature and pressure

The invention provides a method for preparing a formamide compound by using MCOF to catalyze CO2 as a carbon source at normal temperature and pressure, and belongs to the technical field of chemistry and chemical engineering. Under the conditions of normal temperature and normal pressure, CO2 is used as a carbon source to realize N-formylation reaction of various amine substrates. The method has the advantages that the reaction system uses the metal ion-doped two-dimensional covalent organic framework MCOF as the catalyst, CO2 is reduced at normal temperature and normal pressure to provide acyl, high-pressure hydrogen and toxic CO are prevented from being used, and the reaction conditions are mild (normal temperature and normal pressure). According to the method for preparing the formamide, the greenhouse gas carbon dioxide serves as a carbon source, the cost is low, operation is easy, reaction conditions are mild (normal temperature and normal pressure), the yield of the prepared formamide product is excellent (99%), and a green synthesis method is provided for N-acylation reaction.