50901-46-7

Basic information

• Product Name: Ethanone, 1-(4-pyridazinyl)- (9CI)
• Synonyms: 1-(Pyridazin-4-yl)ethanone;Ethanone, 1-(4-pyridazinyl)-;4-Acetylpyridazine;Methyl 4-pyridazinyl ketone;1-(pyridazin-4-yl)ethan-1-one;1-(Pyridazin-4-yl);Ethanone, 1-(4-pyridazinyl)- (9CI)
• CAS NO: 50901-46-7
• Molecular Formula: C₆H₆N₂O
• Molecular Weight: 122.12464
• Product Categories: ACETYLGROUP
• Mol File: 50901-46-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 69-70℃
• Boiling Point: 285.872 °C at 760 mmHg
• Flash Point: 131.02 °C
• Appearance: /Solid
• Density: 1.136±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.003mmHg at 25°C
• Refractive Index: 1.516
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 0.50±0.10(Predicted)
• CAS DataBase Reference: Ethanone, 1-(4-pyridazinyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(4-pyridazinyl)- (9CI)(50901-46-7)
• EPA Substance Registry System: Ethanone, 1-(4-pyridazinyl)- (9CI)(50901-46-7)

Safety Data

• Hazardous Substances Data: 50901-46-7(Hazardous Substances Data)

Usage

General Description

Ethanone, 1-(4-pyridazinyl)- (9CI) is a chemical compound classified under the Chemical Abstracts Service (CAS) identifier of 35622-39-2, uniquely identified by its molecular structure. This chemical, also referred to as 1-(4-Pyridazinyl)ethanone, belongs to the class of organic compounds known as pyridazines and derivatives. Specific properties include a relatively moderate molecular weight and non-volatile, stable state at room temperature. Its spectrum of applications is broad, often used in chemical and pharmaceutical manufacturing. As with many chemical compounds, its exact effects, toxicity, and safety handling measures require professional standard procedures to prevent any harm or damaging impacts.

InChI:InChI=1/C6H6N2O/c1-5(9)6-2-3-7-8-4-6/h2-4H,1H3

Upstream product

• 39123-39-2 ethyl pyridazine-4-carboxylate 
• 917-54-4 methyllithium 
• 75-52-5 nitromethane 
• 50901-42-3 pyridazine-4-carbaldehyde 
• 288-32-4 1H-imidazole 
• 2075-45-8 4-bromo-1H-pyrazole 
• 50681-25-9 pyridazine-4-carboxylic acid 
• 530-62-1 1,1'-carbonyldiimidazole 
• 823189-69-1 N-methoxy-N-methylpyridazine-4-carboxamide 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 124436-43-7 N'-[1-Pyridazin-4-yl-eth-(E)-ylidene]-hydrazinecarbodithioic acid methyl ester 
• 129593-86-8 6-(4-{N'-[1-Pyridazin-4-yl-eth-(E)-ylidene]-hydrazino}-phenyl)-4,5-dihydro-2H-pyridazin-3-one 
• 2075-45-8 4-bromo-1H-pyrazole 
• 288-32-4 1H-imidazole 

Relevant articles and documents

PYRIDAZINONE DERIVATIVES AND USE THEREOF AS P2X7 RECEPTOR INHIBITORS

Novel pyridazinone compounds of formula (I), which inhibit the purinergic P2X7 receptor and are useful for prevention, therapy and improvement of inflammatory and immunological diseases.

Pyridazines.LI. On the Reactivity of Pyridazinecarbaldehydes towards Selected Active-Hydrogen Compounds

Reactions of 3-pyridazinecarbaldehyde and 3-pyridazinecarbaldehyde with various active methylene carbanions were studied.The products obtained in Knoevenagel reactions, Wittig-Horner-Emmons reactions, and Hantzsch-type reactions are presented.

ACIDIFYING EFFECTS OF AZA GROUPS IN THE NH ACIDITY OF AMINOAZINES AND THE CH ACIDITY OF ACETYLAZINES

The pK values for a series of aminoazines and acetylazines containing one, two, or three aza groups in the ring were determined in dimethyl sulfoxide.There is a good linear correlation between pK values of the investigated NH and CH acids.The acidifying effects (ΔpK) of the aza groups at positions 2, 3, or 4 in relation to the side chain were determined and had values of 3.1, 2.4, and 4.5 logarithmic units in the aminoazines and 3.5, 2.9 and 4.8 logarithmic units respectively in the acetylazines.Except in the case of two ortho-located aza groups the effects are additive.Compared with dimethyl sulfoxide water has a differentiating effect on the acidity of the aminoazines, and this is explained by the formation of hydrogen bonds between the molecules of the proton-donating solvent and the aza groups of the anions of the aminoazines.