51-63-8 Usage
Chemical Properties
white powder
Originator
Dexedrine Sulfate,SKF,US,1944
Uses
Amfetamine
Manufacturing Process
Two mols, for example, 270 grams, of racemic α-methylphenethylamine base
are reacted with one mol (150 grams) of d-tartaric acid, thereby forming dl-αmethylphenethylamine d-tartrate, a neutral salt. The neutral salt thus
obtained is fully dissolved by the addition of sufficient, say about 1 liter, of
absolute ethanol, and heating to about the boiling point. The solution is then
allowed to cool to room temperature with occasional stirring to effect
crystallization. The crystals are filtered off and will be found to contain a
preponderance of the levo enantiomorph.The residual solid in the mother liquors is repeatedly and systematically
crystallized, yielding a further fraction of 1-α-methylphenethylamine d-tartrate
which may be purified by recrystallization. d-α-Methylphenethylamine may be
readily recovered from the mother liquors by the addition of tartaric acid
thereto for the formation of acid tartrates and separation of d-αmethylphenethylamine d-bitartrate by crystallization.
The free base of either optical isomer may be obtained by addition to the dtartrate in the case of the levo isomer and the d-bitartrate in the case of the
dextro isomer of alkali in excess, as, for example, by the addition of an
aqueous solution of caustic soda, which will cause the base to separate as an oil which may be recovered and purified by any well-known procedure. The
base is exactly neutralized with sulfuric acid to give the sulfate.
Therapeutic Function
Central stimulant
Biological Activity
CNS stimulant. Targets monoamine transporters to elevate synaptic levels of noradrenalin, dopamine and serotonin.
Safety Profile
Poison by ingestion,
intraperitoneal, subcutaneous, and
intravenous routes. A human teratogen that
causes developmental abnormalities of the
central nervous system. Experimental
reproductive effects including other
teratogenic effects. A habit-forming
stimulant. When heated to decomposition it
emits very toxic fumes of SO, and NO,. See
also other benzidrine compounds and
SULFATES.
Check Digit Verification of cas no
The CAS Registry Mumber 51-63-8 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 1 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 51-63:
(4*5)+(3*1)+(2*6)+(1*3)=38
38 % 10 = 8
So 51-63-8 is a valid CAS Registry Number.
InChI:InChI=1/C9H13N.H2O4S/c1-8(10)7-9-5-3-2-4-6-9;1-5(2,3)4/h2-6,8H,7,10H2,1H3;(H2,1,2,3,4)/t8-;/m0./s1
51-63-8Relevant articles and documents
METHOD FOR MAKING PHARMACEUTICAL COMPOUNDS
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Page/Page column 3-4, (2010/06/13)
A method of making a phenylethylamine of formula B: wherein R2, R3, R4, R5, R6, Rα, Rβ and Rn are each independently selected from hydrogen, alkyl, acyl, aryl, amido, amino acids, sugars and nucleotides. The method includes the reduction of a compound of formula A in the absence of base: wherein R2, R3, R4, R5, R6, Rα, Rβ and Rn are as defined above.
This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.